Normalization of creatine kinase values in a case of rhabdomyolysis during daptomycin treatment
Ferrández, Olivia (Hospital del Mar (Barcelona, Catalunya))
Urbina, Olatz (Hospital del Mar (Barcelona, Catalunya))
Luque, Sònia (Hospital del Mar (Barcelona, Catalunya))
Espona, Mercè (Hospital del Mar (Barcelona, Catalunya))
Berenguer, Nuria (Hospital del Mar (Barcelona, Catalunya))
Grau, Santiago (Hospital del Mar (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Date:	2013
Abstract:	A 41-year-old woman presented in the Emergency Department with suspected compartment syndrome of lower left leg (creatine kinase [CK]: 12,502 IU/L, Cr: 4. 31 mg/dL). Fasciotomy of the four limb compartments was conducted. By day 2, the patient presented oliguria during previous 24 h, so daily intermittent dialysis was carried out. On day 12, the patient presented an episode of bacteremia due to Staphylococcus hominis. Treatment with vancomycin was initiated and was changed after 4 days to daptomycin due to unsatisfactory clinical progression (6 mg/kg every 48 h, according to renal function and patient's weight) (CK: 2,972 IU/L). After 15 days of treatment, the dose of daptomycin was increased to 6 mg/kg every 24 h (CrCL: 46 mL/min, CK: 83 IU/L). The antibiotic was continued for another 4 days. Fourteen days later, the patient was discharged (CK: 26 IU/L). Daptomycin could be prescribed in some patients with elevated CK values. A cut-off value of baseline CK for use of daptomycin needs to be determined.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra, i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Creatine kinase ; Daptomycin ; Rhabdomyolysis
Published in:	Indian Journal of Pharmacology, Vol. 45 (2013) , p. 193-194, ISSN 1998-3751

DOI: 10.4103/0253-7613.108321
PMID: 23716901

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