Web of Science: 52 citations, Scopus: 58 citations, Google Scholar: citations
Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy
Lorenzo, O. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Ramírez, E. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Picatoste, B. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Egido, Jesús (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Tuñón, J. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Universitat Autònoma de Barcelona

Date: 2013
Abstract: Diabetic cardiomyopathy is initiated by alterations in energy substrates. Despite excess of plasma glucose and lipids, the diabetic heart almost exclusively depends on fatty acid degradation. Glycolytic enzymes and transporters are impaired by fatty acid metabolism, leading to accumulation of glucose derivatives. However, fatty acid oxidation yields lower ATP production per mole of oxygen than glucose, causing mitochondrial uncoupling and decreased energy efficiency. In addition, the oxidation of fatty acids can saturate and cause their deposition in the cytosol, where they deviate to induce toxic metabolites or gene expression by nuclear-receptor interaction. Hyperglycemia, the fatty acid oxidation pathway, and the cytosolic storage of fatty acid and glucose/fatty acid derivatives are major inducers of reactive oxygen species. However, the presence of these species can be essential for physiological responses in the diabetic myocardium.
Grants: Instituto de Salud Carlos III PI10-00072
Note: Altres ajuts: MISSSI/SAF2009-08367
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Published in: Mediators of Inflammation, Vol. 2013 (october 2013) , ISSN 1466-1861

DOI: 10.1155/2013/461967
PMID: 24288443


11 p, 824.5 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-01-27, last modified 2023-01-26



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