Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention?
Pinazo-Durán, Maria D. (Unitat de Recerca Oftalmològica "Santiago Grisolia")
Gómez-Ulla, Francisco (Foundación RetinaPlus)
Arias Barquet, Lluís (Hospital Universitari de Bellvitge)
Araiz, Javier (Instituto Clínico Quirúrgico de Oftalmología (ICQO))
Casaroli-Marano, Ricardo Pedro (Hospital Clínic i Provincial de Barcelona)
Gallego-Pinazo, Roberto (Hospital Universitari i Politècnic La Fe (València))
García-Medina, Jose J. (Unitat de Recerca Oftalmològica "Santiago Grisolia")
López-Gálvez, Maria Isabel (Hospital de Valladolid)
Manzanas, Lucía (Hospital de Valladolid)
Salas, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Zapata, Miguel Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Diaz-Llopis, Manuel (Hospital Universitari i Politècnic La Fe (València))
García-Layana, Alfredo (Universidad de Navarra)
Universitat Autònoma de Barcelona

Fecha:	2014
Resumen:	Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids ( ω -3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and ω -3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of ω -3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and ω -3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	Journal of Ophthalmology, Vol. 2014 (january 2014) , ISSN 2090-0058

DOI: 10.1155/2014/901686
PMID: 24672708

15 p, 954.6 KB

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