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Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
Annibali, Daniela (University of California)
Whitfield, Jonathan R. (Vall d'Hebron Institut d'Oncologia)
Favuzzi, Emilia (Università La Sapienza)
Jauset, Toni (Universitat Autònoma de Barcelona)
Serrano, Erika (Universitat Autònoma de Barcelona)
Cuartas, Isabel (Universitat Autònoma de Barcelona)
Redondo Campos, Sara (Universitat Autònoma de Barcelona)
Folch, Gerard (Universitat Autònoma de Barcelona)
Gonzàlez Juncà, Alba (Universitat Autònoma de Barcelona)
Sodir, Nicole M. (University of Cambridge)
Massó Vallés, Daniel (Universitat Autònoma de Barcelona)
Beaulieu, Marie-Eve (Universitat Autònoma de Barcelona)
Swigart, Lamorna B. (University of California)
Mc Gee, Margaret M. (University College Dublin)
Somma, Maria Patrizia (Università La Sapienza)
Nasi, Sergio (Università La Sapienza)
Seoane Suárez, Joan (Institució Catalana de Recerca i Estudis Avançats (ICREA))
Evan, Gerard I. (University of Cambridge)
Soucek, Laura (Universitat Autònoma de Barcelona)

Date: 2014
Abstract: Gliomas are the most common primary tumours affecting the adult central nervous system and respond poorly to standard therapy. Myc is causally implicated in most human tumours and the majority of glioblastomas have elevated Myc levels. Using the Myc dominant negative Omomyc, we previously showed that Myc inhibition is a promising strategy for cancer therapy. Here, we preclinically validate Myc inhibition as a therapeutic strategy in mouse and human glioma, using a mouse model of spontaneous multifocal invasive astrocytoma and its derived neuroprogenitors, human glioblastoma cell lines, and patient-derived tumours both in vitro and in orthotopic xenografts. Across all these experimental models we find that Myc inhibition reduces proliferation, increases apoptosis and remarkably, elicits the formation of multinucleated cells that then arrest or die by mitotic catastrophe, revealing a new role for Myc in the proficient division of glioma cells. Myc has been implicated in the development of multiple types of cancer. Here, the authors explore the therapeutic potential and mechanism of action of Myc inhibition in mouse and human models of glioblastoma, an aggressive type of tumour that is often resistant to conventional therapy.
Note: Número d'acord de subvenció EC/FP7/205819
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra, i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Published in: Nature communications, Vol. 5 (August 2014) , art. 4632, ISSN 2041-1723

DOI: 10.1038/ncomms5632
PMID: 25130259

11 p, 1.8 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-01-29, last modified 2020-11-23

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