Annotated features of domestic cat - Felis catus genome
Tamazian, Gaik (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Simonov, Serguei (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Dobrynin, Pavel (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Makunin, Alexey (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Logachev, Anton (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Komissarov, Aleksey (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Shevchenko, Andrey (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Brukhin, Vladimir (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Cherkasov, Nikolay (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Svitin, Anton (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Koepfli, Klaus-Peter (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Pontius, Joan (Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University)
Driscoll, Carlos A. (Laboratory of Neurogenetics, NIAAA)
Blackistone, Kevin (Laboratory of Neurogenetics, NIAAA)
Barr, Cristina (Laboratory of Neurogenetics, NIAAA)
Goldman, David (Laboratory of Neurogenetics, NIAAA)
Antunes, Agostinho (CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto)
Quilez Oliete, Javier (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Lorente-Galdos, Belen (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Alkan, Can (Department of Computer Engineering, Bilkent University)
Marques-Bonet, Tomas 1975- (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Menotti-Raymond, Marylin (Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research)
David, Victor A. (Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research)
Narfström, Kristina (Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri)
O'Brien, Stephen J. (Oceanographic Center, Nova Southeastern University)

Date:	2014
Abstract:	Domestic cats enjoy an extensive veterinary medical surveillance which has described nearly 250 genetic diseases analogous to human disorders. Feline infectious agents offer powerful natural models of deadly human diseases, which include feline immunodeficiency virus, feline sarcoma virus and feline leukemia virus. A rich veterinary literature of feline disease pathogenesis and the demonstration of a highly conserved ancestral mammal genome organization make the cat genome annotation a highly informative resource that facilitates multifaceted research endeavors. Here we report a preliminary annotation of the whole genome sequence of Cinnamon, a domestic cat living in Columbia (MO, USA), bisulfite sequencing of Boris, a male cat from St. Petersburg (Russia), and light 30× sequencing of Sylvester, a European wildcat progenitor of cat domestication. The annotation includes 21,865 protein-coding genes identified by a comparative approach, 217 loci of endogenous retrovirus-like elements, repetitive elements which comprise about 55. 7 % of the whole genome, 99,494 new SNVs, 8,355 new indels, 743,326 evolutionary constrained elements, and 3,182 microRNA homologues. The methylation sites study shows that 10. 5 % of cat genome cytosines are methylated. An assisted assembly of a European wildcat, Felis silvestris silvestris, was performed; variants between F. silvestris and F. catus genomes were derived and compared to F. catus. The presented genome annotation extends beyond earlier ones by closing gaps of sequence that were unavoidable with previous low-coverage shotgun genome sequencing. The assembly and its annotation offer an important resource for connecting the rich veterinary and natural history of cats to genome discovery.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Felis catus ; Domestic cat ; Felis silvestris silvestris ; European wildcat ; Genome sequence ; Annotation ; Assembly
Published in:	GigaScience, Vol. 3 (august 2014) , p. 13, ISSN 2047-217X

DOI: 10.1186/2047-217X-3-13
PMID: 25143822

3 p, 131.9 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles