Restricted dog leucocyte antigen (DLA) class II haplotypes and genotypes in Beagles
Soutter, Francesca (University of London. Royal Veterinary College (Hatfield, Regne Unit))
Kennedy, Lorna J. (Centre for Integrated Genomic Medical Research, University of Manchester)
Ollier, William E. R. (Centre for Integrated Genomic Medical Research, University of Manchester)
Solano Gallego, Laia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Catchpole, Brian (University of London. Royal Veterinary College (Hatfield, Regne Unit))

Fecha:	2015
Resumen:	Beagles are commonly used in vaccine trials as part of the regulatory approval process. Genetic restriction within this breed and the impact this might have on vaccine responses are rarely considered. This study was designed to characterise diversity of dog leucocyte antigen (DLA) class II genes in a breeding colony of laboratory Beagles, whose offspring are used in vaccine studies. DLA haplotypes were determined by PCR and sequence-based typing from genomic DNA extracted from blood. Breeding colony Beagles had significantly different DLA haplotype frequencies in comparison with pet Beagles and both groups showed limited DLA diversity. Restricted DLA class II genetic variability within Beagles might result in selective antigen presentation and vaccine responses that are not necessarily representative of those seen in other dog breeds.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Beagle ; Dog leucocyte antigen ; Major histocompatibility complex
Publicado en:	The veterinary journal, Vol. 203 (march 2015) , p. 345-347, ISSN 1532-2971

DOI: 10.1016/j.tvjl.2014.12.032
PMID: 25634081

3 p, 171.7 KB

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