Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines
Olivan, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rigau, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Garcia, M.. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Montes, Melania (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Sequeiros, T. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Regis, Lucas (Hospital Universitari Vall d'Hebron)
Celma, Ana (Hospital Universitari Vall d'Hebron)
Planas, J. (Hospital Universitari Vall d'Hebron)
Placer, José (Hospital Universitari Vall d'Hebron)
Reventós, J. (Institut d'Investigació Biomèdica de Bellvitge)
de Torres, Inés (Hospital Universitari Vall d'Hebron)
Doll, Andreas (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Morote Robles, Juan. (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Fecha:	2015
Resumen:	Nowadays prostate cancer is the most common solid tumor in men from industrialized countries and the second leading cause of death. At the ages when PCa is usually diagnosed, mortality related to cardiovascular morbidity is high; therefore, men at risk for PCa frequently receive chronic lipid-lowering and antiplatelet treatment. The aim of this study was to analyze how chronic treatment with statins, aspirin, and their combination influenced the risk of PCa detection. The tumorigenic properties of these treatments were evaluated by proliferation, colony formation, invasion, and migration assays using different PCa cell lines, in order to assess how these treatments act at molecular level. The results showed that a combination of statins and aspirin enhances the effect of individual treatments and seems to reduce the risk of PCa detection (OR: 0. 616 (95% CI: 0. 467-0. 812), P < 0. 001). However, if treatments are maintained, aspirin (OR: 1. 835 (95% CI: 1. 068-3. 155), P = 0. 028) or the combination of both drugs (OR: 3. 059 (95% CI: 1. 894-4. 939), P < 0. 001) represents an increased risk of HGPCa. As observed at clinical level, these beneficial effects in vitro are enhanced when both treatments are administered simultaneously, suggesting that chronic, concomitant treatment with statins and aspirin has a protective effect on PCa incidence.
Ayudas:	Instituto de Salud Carlos III CD12-00475 Ministerio de Ciencia e Innovación RD12-0036-0035
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	BioMed Research International, Vol. 2015 (january 2015) , ISSN 2314-6141

DOI: 10.1155/2015/762178
PMID: 25649906

11 p, 2.3 MB

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