Evidence of Inhaled Tobramycin in Non-Cystic Fibrosis Bronchiectasis
Vendrell, Montserrat (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Muñoz, Gerard (Hospital Universitari de Girona Doctor Josep Trueta)
De Gracia, Javier (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2015
Abstract:	There is currently less experience with inhaled tobramycin in non-cystic fibrosis bronchiectasis than in cystic fibrosis (CF). Intravenous formulation and solution for inhalation (TSI) have been studied in non-CF bronchiectasis patients with chronic P. aeruginosa bronchial infection. An improvement in clinical parameters and a reduction in bacterial density have been shown with both inhaled solutions in these patients. However, further trials are needed to determine the most effective dose and administration protocol in these patients. Based on the current evidence, recommendations cannot be made regarding the use of TSI to treat exacerbations. Although no systemic toxicity has been reported in studies specifically investigating this treatment, patients with known kidney disease or ear disorders should be treated with caution. Adverse respiratory effects are reported to be more common in non-CF patients than in CF patients, who tend to be non-smokers and younger. Research is being conducted into the possibility of combining tobramycin with other antibiotics to increase its antibacterial activity. In this review we will present and discuss the published evidence regarding the use of inhaled tobramycin in non-CF bronchiectasis.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bronchiectasis ; Inhaled ; Tobramycin
Published in:	The Open Respiratory Medicine Journal, Vol. 9 (march 2015) , p. 30-36, ISSN 1874-3064

DOI: 10.2174/1874306401509010030
PMID: 25893022

7 p, 1.5 MB

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