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Retrospective biodosimetry using translocation frequency in a stable cell of occupationally exposed to ionizing radiation
Cho, Min Su (Yonsei University Wonju College of Medicine. Department of Surgery,)
Lee, Jin Kyung (Korea Institute of Radiological and Medical Sciences)
Bae, Keum Seok (Yonsei University Wonju College of Medicine. Department of Surgery)
Han, Eun-Ae (Korea Institute of Radiological and Medical Sciences)
Jang, Seong Jae (Korea Institute of Radiological and Medical Sciences)
Ha, Wi-Ho (Korea Institute of Radiological and Medical Sciences)
Lee, Seung-Sook (Korea Institute of Radiological and Medical Sciences)
Barquinero, J. F. (Joan Francesc) (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Kim, Wan Tae (Korea Institute of Nuclear Safety)

Fecha: 2015
Resumen: Two cases of hematological malignancies were reported in an industrial radiography company over a year, which were reasonably suspected of being consequences of prolonged exposure to ionizing radiation because of the higher incidence than expected in the general population. We analyzed chromosomal aberrations in the peripheral blood lymphocytes from the other workers who had been working under similar circumstances as the patients in the company. Among the subjects tested, 10 workers who belonged to the highest band were followed up periodically for 1. 5 years since the first analysis. The aim of this study was to clarify pertinence of translocation analysis to an industrial set-up where chronic exposure was commonly expected. To be a useful tool for a retrospective biodosimetry, the aberrations need to be persistent for a decade or longer. Therefore we calculated the decline rates and half-lives of frequency for both a reciprocal translocation and a dicentric chromosome and compared them. In this study, while the frequency of reciprocal translocations was maintained at the initial level, dicentric chromosomes were decreased to 46. 9% (31. 0–76. 5) of the initial frequency over the follow-up period. Our results support the long-term stability of reciprocal translocation through the cell cycle and validate the usefulness of translocation analysis as a retrospective biodosimetry for cases of occupational exposure.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Translocation ; Retrospective biodosimetry ; Stable cells ; Occupational exposure
Publicado en: Journal of radiation research, Vol. 56, issue 4 (Jul. 2015) , p. 709-716, ISSN 1349-9157

PMID: 25922373
DOI: 10.1093/jrr/rrv028


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