Web of Science: 4 citas, Scopus: 4 citas, Google Scholar: citas,
Diets high in corn oil or extra-virgin olive oil differentially modify the gene expression profile of the mammary gland and influence experimental breast cancer susceptibility
Moral Cabrera, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Escrich Navarro, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Solanas i Garcia, Montserrat (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Vela Sarrión, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Ruiz de Villa, M. Carme (Universitat de Barcelona)
Escrich Escriche, Eduard (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Fecha: 2015
Resumen: Nutritional factors, especially dietary lipids, may have a role in the etiology of breast cancer. We aimed to analyze the effects of high-fat diets on the susceptibility of the mammary gland to experimental malignant transformation. Female Sprague–Dawley rats were fed a low-fat, high-corn-oil, or high-extra-virgin olive oil (EVOO) diet from weaning or from induction. Animals were induced with 7,12-dimethylbenz[a]anthracene at 53 days and euthanized at 36, 51, 100 and 246 days. Gene expression profiles of mammary glands were determined by microarrays. Further molecular analyses were performed by real-time PCR, TUNEL and immunohistochemistry. Carcinogenesis parameters were determined at 105 and 246 days. High-corn-oil diet increased body weight and mass when administered from weaning. The EVOO diet did not modify these parameters and increased the hepatic expression of UCP2, suggesting a decrease in intake/expenditure balance. Both diets differentially modified the gene expression profile of the mammary gland, especially after short dietary intervention. Corn oil down-regulated the expression of genes related to immune system and apoptosis, whereas EVOO modified the expression of metabolism genes. Further analysis suggested an increase in proliferation and lower apoptosis in the mammary glands by effect of the high-corn-oil diet, which may be one of the mechanisms of its clear stimulating effect on carcinogenesis. The high-corn-oil diet strongly stimulates mammary tumorigenesis in association with modifications in the expression profile and an increased proliferation/apoptosis balance of the mammary gland. The online version of this article (doi:10. 1007/s00394-015-0958-2) contains supplementary material, which is available to authorized users.
Nota: Altres ajuts: This work was supported by Grants from "Fundación Patrimonio Comunal Olivarero" (FPCO2008-165.396; FPCO2013-CF611.084), "Organización Interprofesional del Aceite de Oliva Español" (OIP2009-165.646, "Departament de Salut i d'Agricultura, Alimentació i Acció Rural de la Generalitat de Catalunya" (GC2010-165.000)
Nota: Número d'acord de subvenció MCYT/AGL2006-07691
Nota: Número d'acord de subvenció MICINN/AGL2011-24778
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Extra-virgin olive oil ; Corn oil ; Dietary lipids ; Mammary gland ; Experimental tumors ; Gene expression profile
Publicado en: European Journal of Nutrition, Vol. 55 (June 2015) , p. 1397-1409, ISSN 1436-6215

PMID: 26091908
DOI: 10.1007/s00394-015-0958-2


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