Pseudomonas aeruginosa ventilator-associated pneumonia management
Ramírez-Estrada, Sergio (Hospital Universitari Vall d'Hebron)
Borgatta, Barbara (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rello, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2016
Abstract:	Ventilator-associated pneumonia is the most common infection in intensive care unit patients associated with high morbidity rates and elevated economic costs; Pseudomonas aeruginosa is one of the most frequent bacteria linked with this entity, with a high attributable mortality despite adequate treatment that is increased in the presence of multiresistant strains, a situation that is becoming more common in intensive care units. In this manuscript, we review the current management of ventilator-associated pneumonia due to P. aeruginosa, the most recent antipseudomonal agents, and new adjunctive therapies that are shifting the way we treat these infections. We support early initiation of broad-spectrum antipseudomonal antibiotics in present, followed by culture-guided monotherapy de-escalation when susceptibilities are available. Future management should be directed at blocking virulence; the role of alternative strategies such as new antibiotics, nebulized treatments, and vaccines is promising.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; Article ; Versió publicada
Subject:	Multidrug-resistant ; ICU ; New-antibiotics ; Adjunctive-therapies ; Care-bundles
Published in:	Infection and drug resistance, Vol. 9 (january 2016) , p. 7-18, ISSN 1178-6973

DOI: 10.2147/IDR.S50669
PMID: 26855594

12 p, 692.1 KB

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