R2d2 drives selfish sweeps in the house mouse
Didion, John P. (Carolina Center for Genome Science)
Morgan, Andrew P. (Carolina Center for Genome Science)
Yadgary, Liran (Carolina Center for Genome Science)
Bell, Timothy A. (Carolina Center for Genome Science)
McMullan, Rachel C. (Carolina Center for Genome Science)
Ortiz de Solorzano, Lydia (Carolina Center for Genome Science)
Britton-Davidian, Janice (Université de Montpellier. Institut des Sciences de l'Evolution)
Bult, Carol J. (The Jackson Laboratory)
Campbell, Karl J. (The University of Queensland. School of Geography, Planning & Environmental Management)
Castiglia, Riccardo (Università degli studi di Roma "La Sapienza")
Ching, Yung-Hao (Tzu Chi University. Department of Molecular Biology and Human Genetics)
Chunco, Amanda J. (Elon University. Department of Environmental Studies)
Crowley, James J. (The University of North Carolina at Chapel Hill. Department of Genetics)
Chesler, Elissa J. (The Jackson Laboratory)
Förster, Daniel W. (Leibniz-Institut für Zoo- und Wildtierforschung. Department of Evolutionary Genetics)
French, John E. (National Institute of Environmental Health Sciences. National Toxicology Program)
Gabriel, Sofia I. (Universidade de Lisboa. Department of Animal Biology)
Gatti, Daniel M. (The Jackson Laboratory)
Garland, Theodore (University of California, Riverside. Department of Biology)
Giagia-Athanasopoulou, Eva B. (University of Patras. Department of Biology)
Giménez, Mabel D. (Universidad Nacional de Misiones (Argentina). Instituto de Biología Subtropical)
Grize, Sofia A. (Universität Zürich. Institute of Evolutionary Biology and Environmental Studies)
Gündüz, İslam (University of Ondokuz Mayis. Department of Biology, Faculty of Arts and Sciences)
Holmes, Andrew (National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism)
Hauffe, Heidi C. (Fondazione Edmund Mach. Department of Biodiversity and Molecular Ecology, Research and Innovation Centre)
Herman, Jeremy S. (National Museums Scotland. Department of Natural Sciences)
Holt, James M. (The University of North Carolina at Chapel Hill. Department of Computer Science)
Hua, Kunjie (The University of North Carolina at Chapel Hill. Department of Genetics)
Jolley, Wesley J. (Island Conservation (Santa Cruz, Califòrnia))
Lindholm, Anna K. (Universität Zürich. Institute of Evolutionary Biology and Environmental Studies)
López-Fuster, María J. (Universitat de Barcelona. Facultat de Biologia)
Mitsainas, George (University of Patras. Department of Biology)
da Luz Mathias, Maria (Universidade de Lisboa. Department of Animal Biology)
McMillan, Leonard (The University of North Carolina at Chapel Hill. Department of Computer Science)
Ramalhinho, Maria da Graça Morgado (Universidade de Lisboa. Department of Animal Biology)
Rehermann, Barbara (National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, Estats Units d'Amèrica))
Rosshart, Stephan P. (National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, Estats Units d'Amèrica))
Searle, Jeremy B. (Cornell University. Department of Ecology and Evolutionary Biology)
Shiao, Meng-Shin (Mahidol University. Faculty of Medicine)
Solano, Emanuela (Università degli studi di Roma "La Sapienza")
Svenson, Karen L. (The Jackson Laboratory)
Thomas-Laemont, Patricia (Elon University. Department of Environmental Studies)
Threadgill, David W. (Texas A&M University. Department of Molecular and Cellular Medicine)
Ventura Queija, Jacinto (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Weinstock, George M. (Jackson Laboratory for Genomic Medicine)
Pomp, Daniel (Carolina Center for Genome Science)
Churchill, Gary A. (The Jackson Laboratory)
Pardo-Manuel de Villena, Fernando (Carolina Center for Genome Science)

Date:	2016
Abstract:	A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether "selfish" genes are capable of fixation-thereby leaving signatures identical to classical selective sweeps-despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2 HC ) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2 HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2 HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.
Grants:	Ministerio de Economía y Competitividad CGL2010-15243 Ministerio de Economía y Competitividad CGL2007-62111
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Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	R2d2 ; Meiotic drive ; Selfish genes ; Selective sweep ; House mouse
Published in:	Molecular biology and evolution, Vol. 33, issue 6 (June 2016) , p. 1381-1395, ISSN 1537-1719

DOI: 10.1093/molbev/msw036
PMID: 26882987

15 p, 1.0 MB

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