Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes
Tiosano, Dov (Technion - Israel Institute of Technology. Rappaport Family Faculty of Medicine)
Audí, Laura (Hospital Universitari Vall d'Hebron)
Climer, Sharlee (Department of Computer Science and Engineering, Washington University)
Zhang, Weixiong (Department of Computer Science and Engineering)
Templeton, Alan R. (Department of Evolutionary and Environmental Biology, University of Haifa)
Fernández Cancio, Mónica (Hospital Universitari Vall d'Hebron)
Gershoni-Baruch, Ruth (Department of Evolutionary and Environmental Biology, University of Haifa)
Sánchez-Muro, José Miguel (Pediatric Service, Area Basica de Salut (ABS))
El Kholy, Mohamed (Department of Pediatrics, Ain Shams University)
Hochberg, Zèev (Technion - Israel Institute of Technology. Rappaport Family Faculty of Medicine)
Universitat Autònoma de Barcelona

Fecha:	2016
Resumen:	The well-documented latitudinal clines of genes affecting human skin color presumably arise from the need for protection from intense ultraviolet radiation (UVR) vs. the need to use UVR for vitamin D synthesis. Sampling 751 subjects from a broad range of latitudes and skin colors, we investigated possible multilocus correlated adaptation of skin color genes with the vitamin D receptor gene (VDR), using a vector correlation metric and network method called BlocBuster. We discovered two multilocus networks involving VDR promoter and skin color genes that display strong latitudinal clines as multilocus networks, even though many of their single gene components do not. Considered one by one, the VDR components of these networks show diverse patterns: no cline, a weak declining latitudinal cline outside of Africa, and a strong in- vs. out-of-Africa frequency pattern. We confirmed these results with independent data from HapMap. Standard linkage disequilibrium analyses did not detect these networks. We applied BlocBuster across the entire genome, showing that our networks are significant outliers for interchromosomal disequilibrium that overlap with environmental variation relevant to the genes' functions. These results suggest that these multilocus correlations most likely arose from a combination of parallel selective responses to a common environmental variable and coadaptation, given the known Mendelian epistasis among VDR and the skin color genes.
Ayudas:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-31
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Epistasis ; Skin color ; Vitamin D ; Linkage disequilibrium ; Network analysis ; Adaptation
Publicado en:	G3, Vol. 6 (february 2016) , p. 1251-1266, ISSN 2160-1836

DOI: 10.1534/g3.115.026773
PMID: 26921301

16 p, 1.3 MB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados