Web of Science: 13 citas, Scopus: 17 citas, Google Scholar: citas,
Insights on adaptive and innate immunity in canine leishmaniosis
Hosein, Shazia (University of London)
Blake, Damer P. (University of London)
Solano Gallego, Laia Maria (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Fecha: 2016
Resumen: Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.
Derechos: This is an article, distributed under the terms of the Creative Commons Attribution licence, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Creative Commons
Lengua: Anglès.
Documento: article ; publishedVersion
Materia: Canine leishmaniosis ; Immunology ; Toll-like receptors ; Cytokine profiles ; T-cell mediated immunity
Publicado en: Parasitology, Vol. 144 (april 2016) , p. 95-115, ISSN 1469-8161

PMID: 27094260
DOI: 10.1017/S003118201600055X

21 p, 319.5 KB

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