Web of Science: 22 citas, Scopus: 21 citas, Google Scholar: citas,
Natural Selection in the Great Apes
Cagan, Alexander (Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany)
Theunert, Christoph (University of California. Department of Integrative Biology,)
Laayouni, Hafid (Universitat Autonòma de Barcelona. Departament de Genètica i de Microbiologia)
Santpere, Gabriel (Yale University School of Medicine. Department of Neuroscience)
Pybus, Marc (Universitat Pompeu Fabra. Departament de Ciencies Experimentals i de la Salut, Institut de Biologia Evolutiva)
Casals, Ferran (Universitat Pompeu Fabra. Genomics Core Facility, Departament de Ciencies Experimentals i de la Salut)
Prüfer, Kay (Max Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics)
Navarro, Arcadi (Institució Catalana de Recerca i Estudis Avançats (ICREA))
Marquès i Bonet, Tomàs, 1975- (Institució Catalana de Recerca i Estudis Avançats (ICREA))
Bertranpetit, Jaume (University of Cambridge. Department of Archaeology and Anthropology, Leverhulme Centre for Human Evolutionary Studies)
Andrés, Aida M. (ax Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics)

Fecha: 2016
Resumen: Natural selection is crucial for the adaptation of populations to their environments. Here, we present the first global study of natural selection in the Hominidae (humans and great apes) based on genome-wide information from population samples representing all extant species (including most subspecies). Combining several neutrality tests we create a multi-species map of signatures of natural selection covering all major types of natural selection. We find that the estimated efficiency of both purifying and positive selection varies between species and is significantly correlated with their long-term effective population size. Thus, even the modest differences in population size among the closely related Hominidae lineages have resulted in differences in their ability to remove deleterious alleles and to adapt to changing environments. Most signatures of balancing and positive selection are species-specific, with signatures of balancing selection more often being shared among species. We also identify loci with evidence of positive selection across several lineages. Notably, we detect signatures of positive selection in several genes related to brain function, anatomy, diet and immune processes. Our results contribute to a better understanding of human evolution by putting the evidence of natural selection in humans within its larger evolutionary context. The global map of natural selection in our closest living relatives is available as an interactive browser at .
Nota: Número d'acord de subvenció MINECO/BFU2013-43726-P
Nota: Número d'acord de subvenció AGAUR/2014/SGR-866
Nota: Número d'acord de subvenció MINECO/BFU2014-55090
Nota: Número d'acord de subvenció EC/FP7/233297
Nota: Número d'acord de subvenció EC/FP7/260372
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Evolution ; Adaptation ; Comparative genomics ; Primates.
Publicado en: Molecular Biology and Evolution, Vol. 33, Núm. 12 (desembre 2016) , p. 3268-3283, ISSN 1537-1719

PMID: 27795229
DOI: 10.1093/molbev/msw215


16 p, 839.7 KB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados

 Registro creado el 2018-02-07, última modificación el 2019-02-06



   Favorit i Compartir