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Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis : A Prospective, Randomized, Double-Blinded Clinical Trial
Joshi Jubert, Nayana (Universitat Autònoma de Barcelona. Departament de cirurgia)
Rodríguez, Luciano (Banc de Sang i Teixits)
Reverté-Vinaixa, Maria Mercedes (Hospital Universitari Vall d'Hebron)
Navarro, Aurora (Banc de Sang i Teixits)

Date: 2017
Abstract: Intra-articular injections of platelet-rich plasma (PRP) to treat symptoms of knee osteoarthritis (OA) have been successfully used in young patients and in the early stages of disease. No previous studies have analyzed outcomes of PRP injections during the late stages. PRP reduces pain and leads to a more effective and lasting functional recovery than corticosteroid with local anesthetic. Randomized controlled trial; Level of evidence, 2. A total of 75 patients with symptomatic knee OA (Kellgren-Lawrence grade 3 to 4) were enrolled in this study between August 2013 and July 2014. Patients were randomized to treatment either with a single leukocyte-reduced PRP or corticosteroid intra-articular injection. The primary variable was visual analog scale assessment at 1 month. Secondary outcomes were the Knee injury and Osteoarthritis Outcome Score (KOOS) and Short Form-36 (SF-36) at 1, 3, and 6 months after treatment. Patient satisfaction at final follow-up was assessed. Both groups were homogeneous and comparable in baseline characteristics. All variables improved in both groups. Statistical differences between groups were not found for the majority of the outcome variables, although the magnitude of improvements tended to be greater in the PRP group. Quality-of-life differences between values at 3 and 6 months versus baseline increased significantly more in the study group (P =. 05 and. 03, respectively), and so did general health perception differences at 6 months (P =. 018). A single PRP intra-articular injection is effective for relieving pain and improving activities of daily living and quality of life in late-stage knee OA. For patients with late-stage knee OA who are 67 years or older, 1 intra-articular injection of PRP has similar results to 1 shot of corticosteroid.
Note: Altres ajuts: Financial support for this study was received in the form of a competitive grant from the Ministry of Health, Social Policy, and Equality of Spain.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Platelet-rich plasma ; Osteoarthritis ; Knee ; Intra-articular injections
Published in: Orthopaedic Journal of Sports Medicine, Vol. 5 (february 2017) , ISSN 2325-9671

DOI: 10.1177/2325967116689386
PMID: 28255569

11 p, 330.6 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-02-08, last modified 2020-11-07

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