Eye movement desensitization and reprocessing therapy versus supportive therapy in affective relapse prevention in bipolar patients with a history of trauma : study protocol for a randomized controlled trial
Moreno Alcázar, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Radua, Joaquim (FIDMAG Germanes Hospitalàries Research Foundation)
Landin-Romero, Ramon (Neuroscience Research Australia)
Blanco Presas, Laura (Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat)
Madre Rull, Mercè (Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Spain)
Reinares, María (Hospital Clínic i Provincial de Barcelona)
Comes, Mercè (Hospital Clínic i Provincial de Barcelona)
Jiménez, Esther (Hospital Clínic i Provincial de Barcelona)
Crespo, José Manuel (Centro de Investigación Biomédica en Red de Salud Mental)
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona)
Pérez Solà, Víctor (Centre Forum Research Unit, Institute of Neuropsychiatry and Addictions (INAD) Hospital del Mar)
Novo, Patricia (Centre Forum Research Unit, Institute of Neuropsychiatry and Addictions (INAD) Hospital del Mar)
Doñate, Marta (Centre Forum Research Unit, Institute of Neuropsychiatry and Addictions (INAD) Hospital del Mar)
Cortizo, Romina (Centre Forum Research Unit, Institute of Neuropsychiatry and Addictions (INAD) Hospital del Mar)
Valiente-Gómez, Alicia (Centre Forum Research Unit, Institute of Neuropsychiatry and Addictions (INAD) Hospital del Mar)
Lupo, Walter (Clínica Logos, Barcelona)
McKenna, Peter J. (FIDMAG Germanes Hospitalàries Research Foundation)
Pomarol-Clotet, Edith (FIDMAG Germanes Hospitalàries Research Foundation)
Amann, Benedikt L. (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Fecha:	2017
Resumen:	Up to 60% of patients with bipolar disorder (BD) have a history of traumatic events, which is associated with greater episode severity, higher risk of comorbidity and higher relapse rates. Trauma-focused treatment strategies for BD are thus necessary but studies are currently scarce. The aim of this study is to examine whether Eye Movement Desensitization and Reprocessing (EMDR) therapy focusing on adherence, insight, de-idealisation of manic symptoms, prodromal symptoms and mood stabilization can reduce episode severity and relapse rates and increase cognitive performance and functioning in patients with BD. This is a single-blind, randomized controlled, multicentre trial in which 82 patients with BD and a history of traumatic events will be recruited and randomly allocated to one of two treatment arms: EMDR therapy or supportive therapy. Patients in both groups will receive 20 psychotherapeutic sessions, 60 min each, during 6 months. The primary outcome is a reduction of affective episodes after 12 and 24 months in favour of the EMDR group. As secondary outcome we postulate a greater reduction in affective symptoms in the EMDR group (as measured by the Bipolar Depression Rating Scale, the Young Mania Rating Scale and the Clinical Global Impression Scale modified for BD), and a better performance in cognitive state, social cognition and functioning (as measured by the Screen for Cognitive Impairment in Psychiatry, The Mayer-Salovey-Caruso Emotional Intelligence Test and the Functioning Assessment Short Test, respectively). Traumatic events will be evaluated by The Holmes-Rahe Life Stress Inventory, the Clinician-administered PTSD Scale and the Impact of Event Scale. The results of this study will provide evidence whether a specific EMDR protocol for patients with BD is effective in reducing affective episodes, affective symptoms and functional, cognitive and trauma symptoms. The trial is registered at ClinicalTrials. gov, identifier: . Registered on 3 December 2015. The online version of this article (doi:10. 1186/s13063-017-1910-y) contains supplementary material, which is available to authorized users.
Ayudas:	Instituto de Salud Carlos III PI07-1278 Instituto de Salud Carlos III PI10-02622 Instituto de Salud Carlos III PI15-02242 Instituto de Salud Carlos III PI14-00292 European Commission CES12-024
Nota:	Altres ajuts: Plan Nacional 2013-2016 with a Miguel Servet Research Contract (MS14/00041). We acknowledge also the generous support by the Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Bipolar disorder ; EMDR therapy ; Supportive therapy ; Psychological trauma ; Treatment
Publicado en:	Trials, Vol. 18 (april 2017) , ISSN 1745-6215

DOI: 10.1186/s13063-017-1910-y
PMID: 28376919

10 p, 476.6 KB

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