Presence of pyrophosphate in bone from an atypical femoral fracture site : a case report
Shabestari, Maziar (Institute of Odontology, Oslo)
Eriksen, Erik Fink (Oslo University Hospital (Oslo, Noruega))
Paschalis, Eleftherios P. (Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK, AUVA Trauma Centre Meidling, Vienna)
Roschger, Paul (Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK, AUVA Trauma Centre Meidling, Vienna)
Gamsjaeger, Sonja (Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK, AUVA Trauma Centre Meidling, Vienna)
Klaushofer, Klaus (Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK, AUVA Trauma Centre Meidling, Vienna)
Berzlanovich, Andrea (Medical University of Vienna, Vienna)
Nogués Solán, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Puig, Lluis (Hospital del Mar (Barcelona, Catalunya))
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona

Fecha:	2017
Resumen:	Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report we present the results of analysis of bone chips from a 74-year old female patient that had been on alendronate, ibandronate and denosumab treatment, and who sustained an atypical femoral fracture, by histology, quantitative backscattered electron imaging, and Raman spectroscopic analysis. The results indicate ongoing osteoclastic resorption, but also several abnormalities: 1) an altered arrangement of osteons; 2) impaired mineralization; 3) the presence of pyrophosphate, which might contribute to the impaired mineralization evident in the present case. Taken together, these changes may contribute to the focally reduced bone strength of this patient.
Nota:	Altres ajuts: The present study was supported by the Allgemeine Unfallversicherungsanstalt (AUVA), research funds of the Austrian workers compensation board, and the Wiener Gebietskrankenkasse (WGKK), Viennese sickness insurance funds.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Atypical femoral fracture ; Pyrophosphate
Publicado en:	Bone Reports, Vol. 6 (march 2017) , p. 81-86, ISSN 2352-1872

DOI: 10.1016/j.bonr.2017.02.006
PMID: 28377987

6 p, 1.3 MB

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