Web of Science: 30 citas, Scopus: 38 citas, Google Scholar: citas,
The burden of chronic spontaneous urticaria is substantial : real‐world evidence from ASSURE-CSU
Maurer, Marcus (Universitätsmedizin Berlin)
Abuzakouk, Mohamed (Cleveland Clinic Abu Dhabi)
Bérard, Frédéric (Université Claude Bernard Lyon 1)
Canonica, W. (IRCCS Istituto Clinico Humanitas)
Oude Elberink, H. (Rijksuniversiteit Groningen)
Giménez‐Arnau, Ana (Parc de Salut Mar. Hospital del Mar)
Grattan, C. (Guy's Hospital)
Hollis, Kelly (RTI Health Solutions)
Knulst, A. (Universitair Medisch Centrum Utrecht)
Lacour, Jean Phillipe (Université Nice Sophia Antipolis)
Lynde, Charles (Lynderm Research)
Marsland, Alexander (Salford Royal Hospital)
McBride, Doreen (RTI Health Solutions)
Nakonechna, Alla (The Royal Liverpool University Hospita)
Ortiz de Frutos, Javier (Hospital Universitario 12 de Octubre)
Proctor, Christina (RTI Health Solutions)
Sussman, Gordon (University of Toronto)
Sweeney, Carolyn (RTI Health Solutions)
Tian, Haijun (Novartis Pharmaceuticals Corporation)
Weller, Karsten (Universitätsmedizin Berlin)
Wolin, Daniel (RTI Health Solutions)
Balp, M.‐M. (Novartis Pharma AG)
Universitat Autònoma de Barcelona

Fecha: 2017
Resumen: Chronic spontaneous urticaria () can be debilitating, difficult to treat, and frustrating for patients and physicians. Real‐world evidence for the burden of is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health‐related quality of life (oL) and work among patients with inadequately controlled , and to describe its humanistic, societal, and economic burden. This international observational study assessed a cohort of 673 adult patients with whose symptoms persisted for ≥12 months despite treatment. Demographics, disease characteristics, and healthcare resource use in the previous 12 months were collected from medical records. Patient‐reported data on urticaria and angioedema symptoms, oL, and work productivity and activity impairment were collected from a survey and a diary. Almost 50% of patients had moderate‐to‐severe disease activity as reported by Urticaria Activity Score. Mean () Dermatology Life Quality Index and Chronic Urticaria Quality of Life Questionnaire scores were 9. 1 (6. 62) and 33. 6 (20. 99), respectively. Chronic spontaneous urticaria markedly interfered with sleep and daily activities. Angioedema in the previous 12 months was reported by 66% of enrolled patients and significantly affected oL. More than 20% of patients reported ≥1 hour per week of missed work; productivity impairment was 27%. These effects increased with increasing disease activity. Significant healthcare resources and costs were incurred to treat . Chronic spontaneous urticaria has considerable humanistic and economic impacts. Patients with greater disease activity and with angioedema experience greater oL impairments.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Angioedema ; Economic burden ; Observational study ; Quality of life ; Urticaria
Publicado en: Allergy, Vol. 72, issue 12 (Dec. 2017) , p. 2005-2016, ISSN 1398-9995

PMID: 28543019
DOI: 10.1111/all.13209


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