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The role of IL‐23 and the IL‐23/TH17 immune axis in the pathogenesis and treatment of psoriasis
Girolomoni, Giampiero (University of Verona)
Strohal, Robert (Federal Academic Teaching Hospital of Feldkirch)
Puig Sanz, Lluís (Universitat Autònoma de Barcelona)
Bachelez, Herve (Institut Imagine)
Barker, Jonathan (King's College London)
Boehncke, Wolf-Henning (University of Geneva)
Prinz, Joerg (University of Munich)

Fecha: 2017
Resumen: Psoriasis is a chronic, immune‐mediated disease affecting more than 100 million people worldwide and up to 2. 2% of the population. The aetiology of psoriasis is thought to originate from an interplay of genetic, environmental, infectious and lifestyle factors. The manner in which genetic and environmental factors interact to contribute to the molecular disease mechanisms has remained elusive. However, the interleukin 23 (‐23)/T‐helper 17 (17) immune axis has been identified as a major immune pathway in psoriasis disease pathogenesis. Central to this pathway is the cytokine ‐23, a heterodimer composed of a p40 subunit also found in ‐12 and a p19 subunit exclusive to ‐23. ‐23 is important for maintaining 17 responses, and levels of ‐23 are elevated in psoriatic skin compared with non‐lesional skin. A number of agents that specifically inhibit ‐23p19 are currently in development for the treatment of moderate‐to‐severe plaque psoriasis, with recent clinical trials demonstrating efficacy with a good safety and tolerability profile. These data support the role of this cytokine in the pathogenesis of psoriasis. A better understanding of the ‐23/17 immune axis is vital and will promote the development of additional targets for psoriasis and other inflammatory diseases that share similar genetic aetiology and pathogenetic pathways.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Publicado en: Journal of the European Academy of Dermatology and Venereology, Vol. 31, Issue 10 (October 2017) , p. 1616-1626, ISSN 1468-3083

PMID: 28653490
DOI: 10.1111/jdv.14433

11 p, 1.5 MB

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