Prevalence of prenatal exposure to substances of abuse : questionnaire versus biomarkers
Chiandetti, Antonella (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Hernandez, Gimena (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Mercadal-Hally, Maria (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Alvarez, Airam (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Andreu-Fernandez, Vicente (Hospital Clínic i Provincial de Barcelona)
Navarro-Tapia, Elisabet (Hospital Clínic i Provincial de Barcelona)
Bastons-Compta, Adriana (Hospital Clínic i Provincial de Barcelona)
Garcia-Algar, Oscar (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)

Fecha:	2017
Resumen:	Alcohol and drugs of abuse consumption in young adults, including women of childbearing age, has experienced significant increase over the past two decades. The use of questionnaires as the only measure to investigate prenatal alcohol and drugs of abuse exposure underestimates the real prevalence of exposure and could mislead to wrong conclusions. Therefore, the aim of this article was to compare reported rates of prenatal alcohol and drugs of abuse consumption with biomarkers of exposure by a comprehensive review of the available literature. We searched MEDLINE and EMBASE databases for articles catalogued between 1992 and 2015. We identified relevant published studies that assessed the comparison between prenatal exposure to alcohol and drugs of abuse assessed by self-reported questionnaire of consumption versus biomarkers of exposure. Thirteen studies were included regarding alcohol consumption, and seven of them about drugs of abuse. Women who admitted consumption during pregnancy by questionnaire varied from 0 to 37% for alcohol, from 0 to 4. 3% for cocaine, and 2. 9% for tetrahydrocannabinol (THC). Positive biomarkers results ranged from 16 to 44% for alcohol, 15. 4% for cocaine, and from 4 to 12. 4% for THC. Biomarkers should always complement questionnaires, as it has been shown that self-report may underestimate prenatal exposure to substances of abuse.
Ayudas:	Instituto de Salud Carlos III PI13-01135 Instituto de Salud Carlos III SAMID/RD12-0026-0003 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014SGR584
Nota:	Altres ajuts: RecerCaixa (OG085818) Fundación Mútua Madrileña (AP150572014)
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article de revisió ; Article ; Versió publicada
Materia:	Prenatal exposure ; Pregnancy ; Questionnaire ; Biomarkers ; Biological matrices ; Substances of abuse ; Alcohol ; Drugs of abuse
Publicado en:	Reproductive health, Vol. 14 (october 2017) , ISSN 1742-4755

DOI: 10.1186/s12978-017-0385-3
PMID: 29070078

12 p, 530.0 KB

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