Web of Science: 7 citations, Scopus: 9 citations, Google Scholar: citations,
Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles
Casals Mercadal, Eudald (Vall d'Hebron Institut de Recerca)
Gusta, Muriel F. (Vall d'Hebron Institut de Recerca)
Cobaleda-Siles, Macarena (Vall d'Hebron Institut de Recerca)
Garcia-Sanz, Ana (Vall d'Hebron Institut de Recerca)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)

Date: 2017
Abstract: Chemotherapeutic agents have limited efficacy and resistance to them limits today and will limit tomorrow our capabilities of cure. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours. In front of this, multimodality has appeared as a promising strategy to overcome resistance. In this context, the use of nanoparticle-based platforms enables many possibilities to address cancer resistance mechanisms. Nanoparticles can act as carriers and substrates for different ligands and biologically active molecules, antennas for imaging, thermal and radiotherapy and, at the same time, they can be effectors by themselves. This enables their use in multimodal therapies to overcome the wall of resistance where conventional medicine crash as ageing of the population advance. In this work, we review the cancer resistance mechanisms and the advantages of inorganic nanomaterials to enable multimodality against them. In addition, we comment on the need of a profound understanding of what happens to the nanoparticle-based platforms in the biological environment for those possibilities to become a reality.
Note: Número d'acord de subvenció EC/FP7/604387
Note: Número d'acord de subvenció MICINN/FJCI-2015-26832
Note: Número d'acord de subvenció AGAUR/2014/SGR-612
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Cancer resistance ; Resistance to treatment ; Inorganic nanoparticles ; Multifunctional ; Multimodality
Published in: Cancer Nanotechnology, Vol. 8, issue 1 (2017) , art. 7, ISSN 1868-6966

PMID: 29104700
DOI: 10.1186/s12645-017-0030-4


19 p, 1.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2018-02-08, last modified 2019-07-11



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