Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
de Madaria, Enrique (Hospital General Universitario de Alicante (Alacant, País Valencià))
Molero, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Bonjoch, Laia (Institut d'Investigacions Biomèdiques de Barcelona)
Casas, Josefina (Institut de Química Avançada de Catalunya)
Cárdenas Jaén, Karina (Hospital General Universitario de Alicante (Alacant, País Valencià))
Montenegro, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Closa Autet, Daniel (Institut d'Investigacions Biomèdiques de Barcelona)
Universitat Autònoma de Barcelona

Fecha:	2018
Resumen:	The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic acid chlorohydrin, in the early stages of acute pancreatitis. We hypothesized that the levels of circulating oleic acid chlorohydrin might be a useful early prognostic biomarker in acute pancreatitis in humans. In a prospective, multicenter cohort study, plasma samples collected within 24 h after presentation in the emergency room from 59 patients with acute pancreatitis and from 9 healthy subjects were assessed for oleic acid chlorohydrin levels. Pancreatitis was mild in 30 patients, moderately severe in 16 and severe in 13. Oleic acid chlorohydrin levels within 24 h after presentation were significantly higher in patients that later progressed to moderate and severe acute pancreatitis. Using 7. 49 nM as the cutoff point, oleic acid chlorohydrin distinguished mild from moderately severe-to-severe pancreatitis with high sensitivity/specificity (96. 6/90. 0%) and positive/negative predictive values (90. 3/96. 4%). Using 32. 40 nM as the cutoff value sensitivity, specificity, positive and negative predictive values were all 100% for severe acute pancreatitis. It was found to be a better prognostic marker than BISAP score, hematocrit at 48 h, SIRS at admission, persistent SIRS or C-reactive protein at 48 h. Oleic acid chlorohydrin concentration in plasma is elevated in patients with acute pancreatitis on admission and correlates with a high degree with the final severity of the disease, indicating that it has potential to serve as an early prognostic marker for acute pancreatitis severity.
Ayudas:	Instituto de Salud Carlos III PI13-00019 Agència de Gestió d'Ajuts Universitaris i de Recerca FI-DGR-2013
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Acute pancreatitis ; Chlorohydrins ; Inflammation ; Fatty acids ; SIRS
Publicado en:	Annals of Intensive Care, Vol. 8 (january 2018) , ISSN 2110-5820

DOI: 10.1186/s13613-017-0346-6
PMID: 29330618

8 p, 975.7 KB

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