Web of Science: 3 citas, Scopus: 4 citas, Google Scholar: citas,
Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1 G93A mice and modulates expression of prognosis biomarkers of the disease
Rando, Amaya (Zaragoza, Spain)
Pastor, Diego (Alicante, Spain)
Viso-León, Mari Carmen (Alicante, Spain)
Martínez, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Manzano, Raquel (Oxford, UK)
Navarro, Xavier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Osta, Rosario (Zaragoza, Spain)
Martínez, Salvador (Alicante, Spain)

Fecha: 2018
Resumen: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis and death. There is no effective treatment for ALS and stem cell therapy has arisen as a potential therapeutic approach. SOD1 mutant mice were used to study the potential neurotrophic effect of bone marrow cells grafted into quadriceps femoris muscle. Bone marrow intramuscular transplants resulted in increased longevity with improved motor function and decreased motoneuron degeneration in the spinal cord. Moreover, the increment of the glial-derived neurotrophic factor and neurotrophin 4 observed in the grafted muscles suggests that this partial neuroprotective effect is mediated by neurotrophic factor release at the neuromuscular junction level. Finally, certain neurodegeneration and muscle disease-specific markers, which are altered in the SOD1 G93A mutant mouse and may serve as molecular biomarkers for the early detection of ALS in patients, have been studied with encouraging results. This work demonstrates that stem cell transplantation in the muscle prolonged the lifespan, increased motoneuron survival and slowed disease progression, which was also assessed by genetic expression analysis.
Nota: Altres ajuts: This study was supported by Red de Terapia Celular, TERCEL (RD12/0019/0024).
Nota: Número d'acord de subvenció ISCIII/RD16-001-0010
Nota: Número d'acord de subvenció ISCIII/SEV-2013-0317
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès
Documento: article ; altres ; publishedVersion
Publicado en: Stem cell research & therapy, Vol. 9 (april 2018) , ISSN 1757-6512

DOI: 10.1186/s13287-018-0843-z
PMID: 29625589


12 p, 3.2 MB

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 Registro creado el 2018-06-18, última modificación el 2020-10-31



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