Scopus: 7 citations, Google Scholar: citations,
A TRPV2 interactome-based signature for prognosis in glioblastoma patients
Doñate-Macián, Pau (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Gómez, Antonio (Centre de Regulació Genòmica (CRG). Barcelona Institute of Science and Technology)
Dégano, Irene R. (Institut de Recerca Mèdica Hospital del Mar (IMIM). Grup d'Epidemiologia i Genètica cardiovascular)
Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)

Date: 2018
Abstract: Proteomics aids to the discovery and expansion of protein-protein interaction networks, which are key to understand molecular mechanisms in physiology and physiopathology, but also to infer protein function in a guilt-by-association fashion. In this study we use a systematic protein-protein interaction membrane yeast two-hybrid method to expand the interactome of TRPV2, a cation channel related to nervous system development. After validation of the interactome in silico, we define a TRPV2-interactome signature combining proteomics with the available physio-pathological data in Disgenet to find interactome-disease associations, highlighting nervous system disorders and neoplasms. The TRPV2-interactome signature against available experimental data is capable of discriminating overall risk in glioblastoma multiforme prognosis, progression, recurrence, and chemotherapy resistance. Beyond the impact on glioblastoma physiopathology, this study shows that combining systematic proteomics with in silico methods and available experimental data is key to open new perspectives to define novel biomarkers for diagnosis, prognosis and therapeutics in disease.
Note: Número d'acord de subvenció MICINN/SAF2010-21385
Note: Número d'acord de subvenció MINECO/BFU2017/87843-R
Note: Número d'acord de subvenció EC/FP7/237120
Note: Número d'acord de subvenció AGAUR/2014/SGR-1628
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: TRPV2 ; Proteomics ; Glioblastoma multiforme ; Gene-disease associations ; Gene signature
Published in: Oncotarget, Vol. 9, Num. 26 (April 2018) , p. 18400-18409, ISSN 1949-2553

DOI: 10.18632/oncotarget.24843
PMID: 29719613

10 p, 2.5 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-06-18, last modified 2021-01-25

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