Web of Science: 15 citations, Scopus: 16 citations, Google Scholar: citations
Concentration-dependent protection by ethanol extract of propolis against γ-ray-induced chromosome damage in human blood lymphocytes
Montoro, A. (Universitat de Valencia. Área de Nutrición y Bromatología)
Barquinero, J. F. (Joan Francesc) (Universitat Autònoma de Barcelona. Unitat d'Antropologia Biològica)
Almonacid, Miguel (Hospital Universitario la Fe. Servicio de Protección Radiológica)
Montoro, A. (Universitat de València. Área de Nutrición y Bromatología)
Sebastià, N. (Universitat de València. Área de Nutrición y Bromatología)
Verdù, G. (Universidad Politécnica de Valencia. Departamento de Ingeniería Química y Nuclear)
Sahuquillo, V. (Hospital Universitari i Politècnic La Fe de Valencia)
Serrano, J. (Dietéticos Intersa)
Saiz, M. (Dietéticos Intersa)
Villaescusa, J.I. (Hospital Universitari i Politècnic La Fe de Valencia)
Soriano, J.M. (Universitat de València. Área de Nutrición y Bromatología)

Date: 2011
Abstract: Radioprotection with natural products may be relevant to the mitigation of ionizing radiation-induced damage in mammalian systems; in this sense, propolis extracts have shown effects such as antioxidant, antitumoral, anti-inflammatory, and immunostimulant. We report for the first time a cytogenetic study to evaluate the radioprotective effect, in vitro, of propolis against radiation-induced chromosomal damage. Lymphocytes were cultured with increasing concentrations of ethanol extract of propolis (EEP), including 20, 40, 120, 250, 500, 750, 1000, and 2000 μg mL and then exposed to 2 Gy γ-rays. A significant and concentration-dependent decrease is observed in the frequency of chromosome aberrations in samples treated with EEP. The protection against the formation of dicentrics was concentration-dependent, with a maximum protection at 120 μg mL of EEP. The observed frequency of dicentrics is described as negative exponential function, indicating that the maximum protectible fraction of dicentrics is approximately 44. Free radical scavenging and antioxidant activities are the mechanisms that these substances use to protect cells from ionizing radiation.
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Language: Anglès
Document: article ; recerca ; publishedVersion
Published in: Evidence-based Complementary and Alternative Medicine, Vol. 2011 (2011) , art. 174853, ISSN 1741-4288

DOI: 10.1155/2011/174853
PMID: 20981159

8 p, 1.9 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-04-24, last modified 2021-03-12

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