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Gene ontology analysis of transcriptome data from DMBA-induced mammary tumors of rats fed a high-corn oil and a high-extra virgin olive oil diet
Escrich Navarro, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Cubedo Culleré, Marta (Universitat de Barcelona. Departament d'Estadística)
Escrich Escriche, Eduard (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Moral Cabrera, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Date: 2019
Abstract: Breast cancer is the most common malignancy in women worldwide, and dietary lipids are important environmental factors influencing its etiology. In this work we present data in relation to the transcriptional effects of two high-fat diets, one high in corn oil (HCO) and one high in extra-virgin olive oil (HOO), administered from weaning or after induction, on 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors. Raw data were deposited at ArrayExpress under accession number E-MTAB-3541. We compared the gene expression profiles of the mammary tumors from the high-fat diet groups with those from the control group, finding different effects of diets depending on timing and type of dietary intervention. Lists of differentially expressed genes were analyzed to find overrepresented categories of biological significance. Here we provide information about the cell functions categories overrepresented in significantly modulated genes by effect of the high-fat diets. Further investigations of such functions are described in "A high corn oil diet strongly stimulates mammary carcinogenesis, while a high extra virgin olive oil diet has a weak effect, through changes in metabolism, immune system function, and proliferation/apoptosis pathways" (Escrich et al. , in press) [1].
Note: Altres ajuts: "Fundación Patrimonio Comunal Olivarero (FPCO)" (FPCO2008-165.396; FPCO2013-CF611.084), "Agencia para el Aceite de Oliva del Ministerio de Agricultura, Alimentación y Medio Ambiente" (AAO2008-165.471), "Organización Interprofesional del Aceite de Oliva Español (OIAOE)" (OIP2009-165.646), "Departaments de Salut i d'Agricultura, Alimentació i Acció Rural de la Generalitat de Catalunya" (GC2010-165.000), FPCO and OIAOE (FPCO-OIP2016-CF614.087). The sponsors had no role in the study design, data collection and analysis and interpretation of the results.
Note: Número d'acord de subvenció MCYT/AGL2006-07691
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Cancer ; Nutrition
Published in: Data in brief, Vol. 22 (Feb. 2019) , p. 104-108, ISSN 2352-3409

PMID: 30581912
DOI: 10.1016/j.dib.2018.11.135


5 p, 210.5 KB

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Articles > Research articles
Articles > Published articles

 Record created 2019-05-06, last modified 2019-07-21



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