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Gold nanoparticles and microwave irradiation inhibit beta-amyloid amyloidogenesis
Araya, Eyleen (Universitat de Barcelona)
Olmedo, Ivonne (Universidad de Chile)
Gómez Bastús, Neus (Institut Català de Nanociència i Nanotecnologia)
Guerrero, Simón (Universidad de Santiago de Chile)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Giralt, Ernest (Universitat de Barcelona)
Kogan, Marcelo J. (Centro para la Investigación Interdisciplinaria Avanzada en Ciencias de Materiales)

Date: 2008
Abstract: Peptide-Gold nanoparticles selectively attached to β-amyloid protein (Aβ) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the Aβ aggregates, inhibiting both the amyloidogenesis and the restoration of the amyloidogenic potential. This novel approach offers a new strategy to inhibit, locally and remotely, the amyloidogenic process, which could have application in Alzheimer's disease therapy. We have studied the irradiation effect on the amyloidogenic process in the presence of conjugates peptide-nanoparticle by transmission electronic microscopy observations and by Thioflavine T assays to quantify the amount of fibrils in suspension. The amyloidogenic aggregates rather than the amyloid fibrils seem to be better targets for the treatment of the disease. Our results could contribute to the development of a new therapeutic strategy to inhibit the amyloidogenic process in Alzheimer's disease.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Aggregation ; Alzheimer's disease ; Nanobiotechnology ; Therapy ; Toxicity
Published in: Nanoscale research letters, Vol. 3 (October 2008) , art. 435, ISSN 1556-276X

DOI: 10.1007/s11671-008-9178-5


9 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-07-19, last modified 2020-08-03



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