Design of a Multifunctional Nanoengineered PLLA Surface by Maximizing the Synergies between Biochemical and Surface Design Bactericidal Effects
Nerantzaki, Maria (Aristotle University of Thessaloniki. Department of Chemistry)
Kehagias, Nikolaos (Institut Català de Nanociència i Nanotecnologia)
Francone, Achille (Institut Català de Nanociència i Nanotecnologia)
Fernández Estévez, Ariadna (Institut Català de Nanociència i Nanotecnologia)
Sotomayor Torres, Clivia M. (Institut Català de Nanociència i Nanotecnologia)
Papi, Rigini (Aristotle University of Thessaloniki. Department of Chemistry)
Choli-Papadopoulou, Theodora (Aristotle University of Thessaloniki. Department of Chemistry)
Bikiaris, Dimitrios (Aristotle University of Thessaloniki. Department of Chemistry)

Date:	2018
Abstract:	Nanotechnology, the manipulation of matter on atomic, molecular, and supramolecular scales, has become the most appealing strategy for biomedical applications and is of great interest as an approach to preventing microbial risks. In this study, we utilize the antimicrobial performance and the drug-loading ability of novel nanoparticles based on silicon oxide and strontium-substituted hydroxyapatite to develop nanocomposite antimicrobial films based on a poly(l-lactic acid) (PLLA) polymer. We also demonstrate that nanoimprint lithography (NIL), a process adaptable to industrial application, is a feasible fabrication technique to modify the surface of PLLA, to alter its physical properties, and to utilize it for antibacterial applications. Various nanocomposite PLLA films with nanosized (black silicon) and three-dimensional (hierarchical) hybrid domains were fabricated by thermal NIL, and their bactericidal activity against Escherichia coli and Staphylococcus aureus was assessed. Our findings demonstrate that besides hydrophobicity the nanoparticle antibiotic delivery and the surface roughness are essential factors that affect the biofilm formation.
Grants:	Ministerio de Economía y Competitividad SEV-2013-0295
Note:	This is an open access article published under an ACS AuthorChoice License. See Standard ACS AuthorChoice/Editors' Choice Usage Agreement - https://pubs.acs.org/page/policy/authorchoice_termsofuse.html
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	ACS omega, Vol. 3, Issue 2 (February 2018) , p. 1509-1521, ISSN 2470-1343

DOI: 10.1021/acsomega.7b01756
PMID: 31458476

13 p, 3.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles