Web of Science: 20 citations, Scopus: 21 citations, Google Scholar: citations
Prospects of optical biosensors for emerging label-free RNA analysis
Carrascosa, Laura G. (Institut Català de Nanociència i Nanotecnologia)
Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia)
Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)

Date: 2016
Abstract: RNA is critical in countless cellular processes, and researchers are constantly discovering new types and attributing them different roles. Consequently, a growing interest in efficient RNA analysis has arisen. However, RNA detection is complicated and generally requires the use of labels. Major efforts are being devoted to conceive new approaches for RNA analysis with no need of markers. Optical biosensing is a highly sensitive approach that circumvents many of conventional methods' limitations. Lately, label-free applications with optical biosensors have been developed for short as well as for long RNAs. The low limits of detection at the pM level enabled by optical biosensors, together with a fast analysis, their reusability and the label-free scheme of operation, clearly highlight them among the most promising next-generation RNA screening platforms. This review covers the most relevant optical biosensor platforms and their potential for enabling sensitive and label-free RNA analysis.
Note: Número d'acord de subvenció MICINN/TEC2012-3428
Note: Número d'acord de subvenció AGAUR/2014/SGR-624
Note: Número d'acord de subvenció MINECO/SEV-2013-0295
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès.
Document: article ; recerca ; acceptedVersion
Subject: RNA ; Optical biosensor ; Label-free detection ; Microdevices ; Plasmonics
Published in: TrAC - Trends in Analytical Chemistry, Vol. 80 (June 2016) , p. 177-189, ISSN 1879-3142

DOI: 10.1016/j.trac.2016.02.018


Postprint
38 p, 3.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-09-23, last modified 2019-11-04



   Favorit i Compartir