Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation
Carrascosa, Laura G. (University of Queensland)
Sina, Abu Ali Ibn (University of Queensland)
Palanisamy, Ramkumar (University of Queensland)
Sepúlveda, Borja (Institut Català de Nanociència i Nanotecnologia)
Otte Ortiz, Marinus Albertus (Institut Català de Nanociència i Nanotecnologia)
Rauf, Sakandar (University of Queensland)
Shiddiky, Muhamad J. A. (University of Queensland)
Trau, Matt (University of Queensland)

Date:	2014
Abstract:	DNA methylation has the potential to be a clinically important biomarker in cancer. This communication reports a real-time and label-free biosensing strategy for DNA methylation detection in the cancer cell line. This has been achieved by using surface plasmon resonance biosensing combined with the highly specific molecular inversion probe based amplification method, which requires only 50 ng of bisulfite treated genomic DNA.
Rights:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Published in:	Chemical communications, Vol. 50, Issue 27 (April 2014) , p. 3585-3588, ISSN 1364-548X

DOI: 10.1039/c3cc49607d

Postprint 4 p, 184.2 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles