Cerebral gliosarcoma with perivascular involvement in a cat
Álvarez, Patricia (Pride Veterinary Centre, Derby. Neurology and Neurosurgery Service)
Wessmann, Annette (Pride Veterinary Centre, Derby. Neurology and Neurosurgery Service)
Pascual, Mireia (BalmesVet. ClínicaVeterinaria (Barcelona))
Comas Solé, Oriol (BalmesVet. ClínicaVeterinaria (Barcelona))
Pi Castro, Dolors (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Fecha:	2019
Resumen:	Case summary A 5-year-old neutered male domestic shorthair cat presented with an 18-month history of facial tics, and progressive general ataxia, weakness, lethargy and anorexia of 2 weeks' duration. MRI of the brain showed a well-defined heterogeneous hyperintense mass on T1-weighted and T2-weighted images, with central hypointensity in the rostral commissure and septum pellucidum, and perilesional hyperintensity in fluid-attenuated inversion recovery, suggestive of perilesional oedema. Gross examination in a transverse section of the brain at the level of the septum pellucidum revealed a 0. 2 cm brown soft mass. Histopathological examination identified a biphasic neoplastic proliferation of mesenchymal and neuroepithelial cell populations. Fusiform cells were predominately distributed in bundles showing a high degree of anisocytosis and marked immune-positive reaction to vimentin immunochemistry, confirming a sarcomatous origin. Additionally, high numbers of astrocytic cells were identified by an intense immunopositive reaction to glial fibrillary acidic protein and negative reaction to oligodendrocyte transcription factor 2 immunochemistry. Vascular invasion of the neoplasia into the wall of a medium branch of the rostral cerebral artery was present (secondary Scherer structures). Based on these characteristics, the tumour was defined as a gliosarcoma. Gliosarcoma is a recognised astrocytoma grade IV anaplastic glial cell tumour with sarcomatous differentiation. Relevance and novel information To our knowledge, this is the first report describing a cerebral gliosarcoma in a cat including clinical, MRI, macroscopic and histopathological features and immunolabelling characteristics.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Català
Documento:	Article ; recerca ; Versió publicada
Materia:	Brain ; Neoplasia ; Glioma ; Histopathology ; Immunohistochemistry ; Scherer structures ; MRI
Publicado en:	Journal of feline medicine and surgery, Vol. 5, Num. 2 (2019) , ISSN 1532-2750

Adreça alternativa: https://scholar.google.cat/scholar?q=Álvarez+Cerebral+gliosarcoma+with+perivascular+involvement
DOI: 10.1177/2055116919879783
PMID: 31636916

6 p, 2.0 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Unitat de Patologia Murina i Comparada
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