Capacitive DNA Detection Driven by Electronic Charge Fluctuations in a Graphene Nanopore
Feliciano, Gustavo T. (Universidade Federal do ABC (Brasil))
Sanz Navarro, Carlos (Institut Català de Nanociència i Nanotecnologia)
Coutinho-Neto, Mauricio Domingues (Universidade Federal do ABC (Brasil))
Ordejon, Pablo (Institut Català de Nanociència i Nanotecnologia)
Scheicher, Ralph H. (Uppsala University. Department of Physics and Astronomy)
Reily Rocha, Alexandre (Universidade Estadual Paulista)

Additional title:	Charge fluctuations in capacitive DNA sequencing with graphene nanopores
Date:	2015
Abstract:	The advent of parallelized automated methods for rapid whole-genome analysis has led to an exponential drop in costs, thus greatly accelerating biomedical research and discovery. Third-generation sequencing techniques, which would utilize the characteristic electrical conductance of the four different nucleotides, could facilitate longer base read lengths and an even lower price per genome. In this work, we propose and apply a quantum-classical hybrid methodology to quantitatively determine the influence of the solvent on the dynamics of DNA and the resulting electron transport properties of a prototypic sequencing device utilizing a graphene nanopore through which the nucleic-acid chain is threaded. Our results show that charge fluctuations in the nucleotides are responsible for characteristic conductance modulations in this system, which can be regarded as a field-effect transistor tuned by the dynamic aqueous environment.
Grants:	Ministerio de Economía y Competitividad FIS2012-37549-C05 Ministerio de Economía y Competitividad SEV-2013-0295
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Subject:	Aqueous environment ; Biomedical research ; Charge fluctuations ; Conductance modulations ; Electrical conductance ; Electronic charges ; Hybrid methodologies ; Whole genome analysis
Published in:	Physical review applied, Vol. 3, Issue 3 (March 2015) , art. 34003, ISSN 2331-7019

DOI: 10.1103/PhysRevApplied.3.034003

Preprint 8 p, 6.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles