Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection
Flores-Chávez, A. (Universidad de Colima. Centro Universitario de Investigaciones Biomédicas (CUIB))
Carrión Rodríguez, José Antonio (Institut Hospital del Mar d'Investigacions Mèdiques)
Forns, Xavier (Hospital Clínic i Provincial de Barcelona)
Ramos-Casals, M. (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut)
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Chronic hepatitis C virus (HCV) infection has been associated with both organ-specific and systemic autoimmune diseases, with cryoglobulinemia being the most frequent associated disease. Experimental, virologic, and clinical evidence have demon-strated a close association between HCV infection and some systemic autoimmune diseases, especially Sjögren's syndrome, but also rheumatoid arthritis and lupus. A higher prevalence of hematological processes has also been described in patients with HCV infection, including cytopenias and lymphoproliferative disorders (B-cell lymphoma). In addition, patients with chronic HCV infection have a higher frequency of other extrahepatic manifestations including endocrine, metabolic and cardiovascular disorders that may worse the prognosis of patients, along with neuropsychiatric manifestations and general symptoms that have a significant influence on the quality of life of the patient. Direct-acting antiviral therapies (DAAs) that have recently begun to be used are providing the opportunity to effectively cure chronic HCV infection and reduce the burden of both hepatic and extrahepatic complications.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Prisons ; Hepacivirus ; Hepatitis C ; Antiviral agents ; Autoinmune diseases ; Lymphoma ; Spain ; Diabetes mellitus
Published in:	Revista Española de Sanidad Penitenciaria, Vol. 19 (2017) , p. 87-97, ISSN 2013-6463

PMID: 29364334

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