Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact : analyses from ASSURE-CSU
Sussman, Gordon ![Identificador ORCID](/img/uab/orcid.ico)
(University of Toronto)
Abuzakouk, Mohamed ![Identificador ORCID](/img/uab/orcid.ico)
(Cleveland Clinic Abu Dhabi)
Bérard, Frédéric ![Identificador ORCID](/img/uab/orcid.ico)
(Claude Bernard University Lyon)
Canonica, G. Walter ![Identificador ORCID](/img/uab/orcid.ico)
(Humanitas University)
Oude Elberink, H. (University Medical Center Groningen. University of Groningen)
Giménez-Arnau, Ana M.. 1961- ,
![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona)
Grattan, Clive
(Guy's and St Thomas' NHS Foundation Trust (Regne Unit))
Hollis, Kelly (RTI Health Solutions)
Hunter, S. (RTI Health Solutions)
Knulst, A.
(University Medical Center)
Lacour, Jean Philippe
(Université Nice Sophia Antipolis)
Lynde, Charles (Lynderm Research)
Marsland, Alexander (University of Manchester)
McBride, Doreen
(RTI Health Solutions)
Maurer, Marcus.
(Charité - Universitätsmedizin Berlin)
Nakonechna, A.
(Royal Liverpool and Broadgreen University Hospitals)
Ortiz de Frutos, J. (Hospital Universitario 12 de Octubre (Madrid))
Reynolds, M. (RTI Health Solutions)
Sweeney, Carolyn (RTI Health Solutions)
Tian, H. (Novartis Pharmaceuticals Corporation)
Weller, Karsten.
(Charité - Universitätsmedizin Berlin)
Wolin, Daniel (RTI Health Solutions)
Balp, Maria Magdalena.
(Novartis Pharma AG)
Universitat Autònoma de Barcelona
Fecha: |
2018 |
Resumen: |
ASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema. This international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (). Physicians abstracted angioedema data from medical records, which were compared with patient-reported data. Patients in the Yes-angioedema category had angioedema reported in the medical record and a patient-reported source. For those in the No-angioedema category, angioedema was reported in neither the medical record nor a patient-reported source. Those in the Misaligned category had angioedema reported in only one source. Statistical comparisons between Yes-angioedema and No-angioedema categories were conducted for measures of activity, health-related quality of life (oL), productivity and healthcare resource utilization (). Regression analyses explored the relationship between Dermatology Life Quality Index () score and angioedema, adjusting for important covariates. Among evaluable patients, 259 (40. 3%), 173 (26. 9%) and 211 (32. 8%) were in the Yes-angioedema, No-angioedema and Misaligned category, respectively. activity and impact on oL, productivity, and was greater for Yes-angioedema patients than No-angioedema patients. After covariate adjustment, mean score was significantly higher (indicating worse oL) for patients with angioedema versus no angioedema (9. 88 vs 7. 27, P < . 001). The Misaligned category had similar results with Yes-angioedema on all outcomes. Angioedema in seems to be under-reported but has significant negative impacts on oL, daily activities, and work compared with no angioedema. |
Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. ![Creative Commons](/img/licenses/by-nc-nd.ico) |
Lengua: |
Anglès |
Documento: |
Article ; recerca ; Versió publicada |
Materia: |
Angioedema ;
Economic burden ;
Observational study ;
Quality of life ;
Urticaria |
Publicado en: |
Allergy, Vol. 73 (july 2018) , p. 1724-1734, ISSN 1398-9995 |
DOI: 10.1111/all.13430
PMID: 29460968
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