Microwave-assisted synthesis of SPION-reduced graphene oxide hybrids for magnetic resonance imaging (MRI)
Llenas, Marina (Institut de Ciència de Materials de Barcelona)
Sandoval, Stefania (Institut de Ciència de Materials de Barcelona)
Costa, Pedro M. (King's College London. Institute of Pharmaceutical Science)
Oró Solé, Judith (Institut de Ciència de Materials de Barcelona)
Lope-Piedrafita, Silvia (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear)
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia)
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science)
Tobias, Gerard (Institut de Ciència de Materials de Barcelona)

Date:	2019
Abstract:	Magnetic resonance imaging (MRI) is a useful tool for disease diagnosis and treatment monitoring. Superparamagnetic iron oxide nanoparticles (SPION) show good performance as transverse relaxation (T) contrast agents, thus facilitating the interpretation of the acquired images. Attachment of SPION onto nanocarriers prevents their agglomeration, improving the circulation time and efficiency. Graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (RGO), are appealing nanocarriers since they have both high surface area and functional moieties that make them ideal substrates for the attachment of nanoparticles. We have employed a fast, simple and environmentally friendly microwave-assisted approach for the synthesis of SPION-RGO hybrids. Different iron precursor/GO ratios were used leading to SPION, with a median diameter of 7. 1 nm, homogeneously distributed along the RGO surface. Good relaxivity (r*) values were obtained in MRI studies and no significant toxicity was detected within in vitro tests following GL261 glioma and J774 macrophage-like cells for 24 h with SPION-RGO, demonstrating the applicability of the hybrids as T-weighted MRI contrast agents.
Grants:	Ministerio de Economía y Competitividad SEV-2015-0496 Ministerio de Economía y Competitividad SEV-2017-0706 Agencia Estatal de Investigación MAT2017-86616-R
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Contrast agents ; Biomedical imaging ; Ultrasmall superparamagnetic iron oxide nanoparticles
Published in:	Nanomaterials, Vol. 9, Issue 10 (October 2019) , art. 1364, ISSN 2079-4991

DOI: 10.3390/nano9101364
PMID: 31554159

16 p, 5.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles