Network-centric interventions to contain the Syphilis epidemic in San Francisco
Juher, David (Universitat de Girona)
Saldaña, Joan (Universitat de Girona)
Kohn, Robert (San Francisco Public Health Department (USA))
Bernstein, Kyle (Centers for Disease Control and Prevention (USA))
Scoglio, Caterina (Kansas State University (USA))

Fecha:	2017
Resumen:	The number of reported early syphilis cases in San Francisco has increased steadily since 2005. It is not yet clear what factors are responsible for such an increase. A recent analysis of the sexual contact network of men who have sex with men with syphilis in San Francisco has discovered a large connected component, members of which have a significantly higher chance of syphilis and HIV compared to non-member individuals. This study investigates whether it is possible to exploit the existence of the largest connected component to design new notification strategies that can potentially contribute to reducing the number of cases. We develop a model capable of incorporating multiple types of notification strategies and compare the corresponding incidence of syphilis. Through extensive simulations, we show that notifying the community of the infection state of few central nodes appears to be the most effective approach, balancing the cost of notification and the reduction of syphilis incidence. Additionally, among the different measures of centrality, the eigenvector centrality reveals to be the best to reduce the incidence in the long term as long as the number of missing links (non-disclosed contacts) is not very large.
Ayudas:	Ministerio de Economía y Competitividad MTM2014-52402-C3-3-P Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1083 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-555
Nota:	Altres ajuts: MPCUdG2016/047 de la Universitat de Girona
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió acceptada per publicar
Materia:	Contact Tracing ; Epidemics ; Homosexuality Male ; Humans ; Incidence ; Male ; Models Theoretical ; San Francisco ; Social Networking ; Syphilis
Publicado en:	Scientific reports, Vol. 7 (July 2017) , art. 6464, ISSN 2045-2322

DOI: 10.1038/s41598-017-06619-9
PMID: 28743879

Postprint 26 p, 983.4 KB

17 p, 2.9 MB

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