Morphological changes of the pancreas after pancreaticoduodenectomy
Quesada, R (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Simón, Clara (Universitat Autònoma de Barcelona)
Radosevic, Aleksandar (Hospital del Mar (Barcelona, Catalunya))
Poves, Ignasi (Hospital del Mar (Barcelona, Catalunya))
Grande, L (Hospital del Mar (Barcelona, Catalunya))
Burdío, Fernando (Hospital del Mar (Barcelona, Catalunya))

Date:	2019
Abstract:	The aim of this retrospective study was thus to evaluate postoperative morphological changes in the remnant pancreas after pancreaticoduodenectomy (PD) associated with postoperative pancreatic fistula (POPF). Fifty-one patients subjected to PD were enrolled in the study and allocated into 2 groups according to the presence (n = 16) or absence of POPF (n = 35). A morphological evaluation of the pancreas was conducted for up to a 20 months follow-up on CT scans and compared between groups. No significant differences were observed in morphology between the groups at the different preoperative and PO intervals, regardless of the clinical relevance of the POPF or POPF grade. However, in the overall patient analysis we observed a significant reduction of the entire pancreas over time. In fact, thickness decreased 0. 4 mm/month, length 1. 2 mm/month and volume 1. 17 cm/month over the PO. The impact of age, POPF, type of anastomosis, surgical technique and PO follow-up (time) was evaluated in a multivariate analysis using the general linear model, but only PO follow-up had a significant influence on the final model (p < 0. 001). A significant reduction on pancreatic parenchyma (thickness, length and volume) occurs after PD with no significant differences between patients with or without POPF.
Grants:	Instituto de Salud Carlos III PI17-00468
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 14517, ISSN 2045-2322

DOI: 10.1038/s41598-019-51173-1
PMID: 31601993

8 p, 1.3 MB

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