Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis
Matas, Jessica (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Llorenç, Victor (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Fonollosa, Alex (Hospital Universitario de Cruces (Barakaldo, País Basc))
Esquinas, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Diaz Valle, David (Hospital Clínico San Carlos (Madrid))
Berasategui, Barbara (Hospital Universitario de Cruces (Barakaldo, País Basc))
Mesquida, Marina (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Artaraz, Joseba (Hospital Universitario de Cruces (Barakaldo, País Basc))
Ríos, José (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Adan Civera, Alfredo (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Aims We aimed to investigate predictive factors for visual and anatomic outcomes in patients with macular edema secondary to non-infectious uveitis. Material and methods We conducted a multicenter, prospective, observational, 12-month follow-up study. Participants included in the study were adults with non-infectious uveitic macular edema (UME), defined as central subfoveal thickness (CST) of >300 μm as measured by spectral domain optical coherence tomography (SD-OCT) and fluid in the macula. Demographic, clinical and tomographic data was recorded at baseline, 1, 3, 6 and 12 months. Foveal-centered SD-OCT exploration was set as the gold-standard determination of UME using a standard Macular Cube 512x128 A-scan, within a 6 x 6 mm area, and the Enhanced High Definition Single-Line Raster. To assess favorable prognosis, the main outcomes analyzed were the best-corrected visual acuity (BCVA) and the CST. Favorable prognosis was defined as sustained improvement of BCVA (2 lines of gain of the Snellen scale) and CST (decrease of 20% of the initial value or <300 μm) within a 12 month period. Results Fifty-six eyes were analyzed. The number of eyes with sustained improvement in the CST was 48 (86. 2%), against 23 (41. 1%) eyes with sustained improvement in BCVA. Favorable prognosis, as defined above, was observed in 18 (32. 1%) eyes. UME prognosis was negatively correlated with baseline foveal thickening, alteration in the vitreo-macular interface and cystoid macular edema. In contrast, bilaterally, systemic disease and the presence of anterior chamber cells were predictive of favorable prognosis. Conclusion Available treatment modalities in UME may avoid chronic UME and improve anatomic outcome. However, the proportion of functional amelioration observed during 12 months of follow-up is lower. Thicker CST, alteration in the vitreo-macular interface and cystoid macular edema may denote less favorable prognosis. Conversely, bilaterally, systemic disease and anterior chamber cells may be associated with favorable prognosis in UME.
Grants:	Instituto de Salud Carlos III PI13-02148
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Fovea Centralis ; Humans ; Macular Edema ; Male ; Middle Aged ; Outcome Assessment (Health Care) ; Prognosis ; Prospective Studies ; Tomography, Optical Coherence ; Uveitis ; Visual Acuity ; Young Adult
Published in:	PloS one, Vol. 14 Núm. 1 (january 2019) , p. e0210799, ISSN 1932-6203

DOI: 10.1371/journal.pone.0210799
PMID: 30677041

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