Screening for epistatic selection signatures : a simulation study
Id-Lahoucine, Samir (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Molina, A. (Universidad de Córdoba. Departamento de Genética)
Cánovas, Angela (University of Guelph. Centre for Genetic Improvement of Livestock. Department of Animal Biosciences)
Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Date:	2019
Abstract:	Detecting combinations of alleles that diverged between subpopulations via selection signature statistics can contribute to decipher the phenomenon of epistasis. This research focused on the simulation of genomic data from subpopulations under divergent epistatic selection (ES). We used D' and F statistics in pairs of loci to scan the whole-genome. The results showed the ability to identify loci under additive-by-additive ES (ES) by reporting large statistical departures between subpopulations with a high level of divergence, while it did not show the same advantage in the other types of ES. Despite this, limitations such as the difficulty to distinguish between the quasi-complete fixation of one locus by ES from other events were observed. However, D' can detect loci under ES by defining a minimum boundary for the minor allele frequency on a multiple subpopulation analysis where ES only takes place in one subset. Even so, the major limitation was distinguishing between ES and single-locus selection (SS); therefore, we can conclude that divergent locus can be also a result of ES. The test conditions with D-statistics of both Ohta (1982a, 1982b) and Black and Krafsur (1985) did not provide evidence to differentiate ES in our simulation framework of isolated subpopulations.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Genètica veterinària
Published in:	Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 1026, ISSN 2045-2322

DOI: 10.1038/s41598-019-38689-2
PMID: 30705409

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