Recent advances in porous nanoparticles for drug delivery in antitumoral applications : inorganic nanoparticles and nanoscale metal-organic frameworks
Baeza, Alejandro (Universidad Complutense de Madrid. Departamento de Química Inorgánica)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Vallet Regí, María (Universidad Complutense de Madrid. Departamento de Química Inorgánica)

Fecha:	2017
Resumen:	Introduction: Nanotechnology has provided new tools for addressing unmet clinical situations, especially in the oncology field. The development of smart nanocarriers able to deliver chemotherapeutic agents specifically to the diseased cells and to release them in a controlled way has offered a paramount advantage over conventional therapy. Areas covered: Among the different types of nanoparticle that can be employed for this purpose, inorganic porous materials have received significant attention in the last decade due to their unique properties such as high loading capacity, chemical and physical robustness, low toxicity and easy and cheap production in the laboratory. This review discuss the recent advances performed in the application of porous inorganic and metal-organic materials for antitumoral therapy, paying special attention to the application of mesoporous silica, porous silicon and metal-organic nanoparticles. Expert opinion: The use of porous inorganic nanoparticles as drug carriers for cancer therapy has the potential to improve the life expectancy of the patients affected by this disease. However, much work is needed to overcome their drawbacks, which are aggravated by their hard nature, exploiting the advantages offered by highly the ordered pore network of these materials.
Ayudas:	Ministerio de Economía y Competitividad MAT2015-64831-R Ministerio de Economía y Competitividad MAT2015-70615-R Ministerio de Economía y Competitividad SEV-2013-0295
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió sotmesa a revisió
Materia:	Cancer nanomedicine ; Porous inorganic nanomaterials ; Mesoporous silica nanoparticles ; Porous silicon nanoparticles ; Metal-organic frameworks
Publicado en:	Expert opinion on drug delivery, Vol. 14, Issue 6 (March 2017) , p. 783-796, ISSN 1744-7593

DOI: 10.1080/17425247.2016.1229298

Preprint 46 p, 884.2 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
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