Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
Escorihuela, Rosa M. (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Capdevila Ortís, Lluís (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació)
Castro, Juan Ramos (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica)
Zaragoza, Maria Cleofé (Laboratorios Viñas (Barcelona))
Maurel, Sara (Universitat Autònoma de Barcelona. Departament de Medicina)
Alegre Martín, José (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Castro-Marrero, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca)

Fecha:	2020
Resumen:	Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) on their association with illness-related complaints. To address this issue, we assessed the value of different diurnal HRV parameters as potential biomarker in CFS/ME and also investigated the relationship between these HRV indices and self-reported symptoms in individuals with CFS/ME. In this case-control study, 45 female patients who met the 1994 CDC/Fukuda definition for CFS/ME and 25 age- and gender-matched healthy controls underwent HRV recording-resting state tests. The intervals between consecutive heartbeats (RR) were continuously recorded over three 5-min periods. Time- and frequency-domain analyses were applied to estimate HRV variables. Demographic and clinical features, and self-reported symptom measures were also recorded. CFS/ME patients showed significantly higher scores in all symptom questionnaires (p < 0. 001), decreased RR intervals (p < 0. 01), and decreased HRV time- and frequency-domain parameters (p < 0. 005), except for the LF/HF ratio than in the healthy controls. Overall, the correlation analysis reached significant associations between the questionnaires scores and HRV time- and frequency-domain measurements (p < 0. 05). Furthermore, separate linear regression analyses showed significant relationships between self-reported fatigue symptoms and mean RR (p = 0. 005), RMSSD (p = 0. 0268) and HFnu indices (p = 0. 0067) in CFS/ME patients, but not in healthy controls. Our findings suggest that ANS dysfunction presenting as increased sympathetic hyperactivity may contribute to fatigue severity in individuals with ME/CFS. Further studies comparing short- and long-term HRV recording and self-reported outcome measures with previous studies in larger CFS/ME cohorts are urgently warranted.
Ayudas:	Ministerio de Economía y Competitividad DEP2015-68538-C2-1-R
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Autonomic dysfunction ; Chronic fatigue syndrome ; Fatigue ; Heart rate variability ; Myalgic encephalomyelitis
Publicado en:	Journal of translational medicine, Vol. 18 (january 2020) , ISSN 1479-5876

DOI: 10.1186/s12967-019-02184-z
PMID: 31906988

12 p, 854.3 KB

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