Chronic Sleep Fragmentation Mimicking Sleep Apnea Does Not Worsen Left-Ventricular Function in Healthy and Heart Failure Mice
Cabrera-Aguilera, Ignacio (Departament of Human Movement Sciences, Faculty of Health Sciences, School of Kinesiology, Universidad de Talca)
Benito, Begoña (Universitat Autònoma de Barcelona. Departament de Medicina)
Tajes, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Gozal, David (Department of Child Health and Child Health Research Institute, The University of Missouri School of Medicine)
Almendros, Isaac (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Farré, Núria (Hospital del Mar (Barcelona, Catalunya))

Fecha:	2020
Resumen:	Aims: Obstructive sleep apnea (OSA) has been associated with heart failure (HF). Sleep fragmentation (SF), one of the main hallmarks of OSA, induces systemic inflammation, oxidative stress and sympathetic activation, hence potentially participating in OSA-induced cardiovascular consequences. However, whether SF per se is deleterious to heart function is unknown. The aim of this study was to non-invasively evaluate the effect of SF mimicking OSA on heart function in healthy mice and in mice with HF. Methods and Results: Forty C57BL/6J male mice were randomized into 4 groups: control sleep (C), sleep fragmentation (SF), isoproterenol-induced heart failure (HF), and mice subjected to both SF+HF. Echocardiography was performed at baseline and after 30 days to evaluate left ventricular end-diastolic (LVEDD) and end-systolic (LVESD) diameters, left ventricular ejection fraction (LVEF) and fraction shortening (FS). The effects of SF and HF on these parameters were assessed by two-way ANOVA. Mice with isoproterenol-induced HF had significant increases in LVEDD and LVESD, as well as a decreases in LVEF and FS (p = 0. 013, p = 0. 006, p = 0. 027, and p = 0. 047, respectively). However, no significant effects emerged with SF (p = 0. 480, p = 0. 542, p = 0. 188, and p = 0. 289, respectively). Conclusion: Chronic SF mimicking OSA did not induce echocardiographic changes in cardiac structure and function in both healthy and HF mice. Thus, the deleterious cardiac consequences of OSA are likely induced by other perturbations associated with this prevalent condition, or result from interactions with underlying comorbidities in OSA patients.
Ayudas:	Ministerio de Economía y Competitividad SAF2017-85574-R
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Sleep apnea ; Sleep breathing disorders ; Heart failure ; Ventricular function ; Sleep fragmentation
Publicado en:	Frontiers in neurology, Vol. 10 (january 2020) , ISSN 1664-2295

DOI: 10.3389/fneur.2019.01364
PMID: 31993015

4 p, 384.4 KB

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