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Adverse Drug Reactions in Selected Wards of the Yangon General Hospital and Yangon Specialty Hospital During the First Quarter of 2019 : An Active Pharmacovigilance Study in Myanmar
May, Lwin Moe (University of Medicine 1, Yangon. Department of Pharmacology)
Figueras, Albert 1961- (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Linn, Ye Htut (University of Medicine 1, Yangon. Department of Pharmacology)
Htike, Maw Than (University of Medicine 1, Yangon. Department of Pharmacology)
San, Mi Kun Kaw (University of Medicine 1, Yangon. Department of Pharmacology)
Pyae, Nyein Chan (University of Medicine 1, Yangon. Department of Pharmacology)
Aye, Khin Hnin (University of Medicine 1, Yangon. Department of Pharmacology)
Aung, Ei Ei (University of Medicine 1, Yangon. Department of Pharmacology)
Win, Nilar (University of Medicine 1, Yangon. Department of Pharmacology)
Thawda, Wine (University of Medicine 1, Yangon. Department of Pharmacology)
Linn, Zin Wah (University of Medicine 1, Yangon. Department of Pharmacology)
Kyaw, Yin Min (University of Medicine 1, Yangon. Department of Pharmacology)
Min, Ya (University of Medicine 1, Yangon. Department of Pharmacology)
Than, Zaw Win (University of Medicine 1, Yangon. Department of Pharmacology)
Khaing, Moe Pan (University of Medicine 1, Yangon. Department of Pharmacology)
Win, Thurein (University of Medicine 1, Yangon. Department of Pharmacology)
Htet, Pyi Phyo (University of Medicine 1, Yangon. Department of Pharmacology)
Aye, Nu Nu (University of Medicine 1, Yangon. Department of Pharmacology)

Date: 2020
Abstract: Previous studies in Europe and the USA have reported a high prevalence of adverse drug reactions (ADRs), but data on local ADRs in Myanmar are sparse. Our objective was to study ADRs in patients admitted to selected wards of Yangon General Hospital (YGH) and Yangon Specialty Hospital (YSH), Myanmar. This was a prospective observational study in three hospital wards during the first quarter of 2019. Suspected ADRs were carefully investigated in a face-to-face interview with each patient and via review of clinical records. Patients transferred to other wards or discharged were followed-up by the researchers until day 28 after admission. ADRs were divided into those that (1) led to the admission and (2) occurred during the hospital stay or after discharge (up to day 28 after admission). A total of 65 ADRs were identified, with 47 (29. 4%) of 160 patients experiencing at least one ADR. Among these, 16 (24. 6%) had led to hospital admission and 49 (75. 4%) occurred in 31 patients during their hospital stay. Of 160 patients, 21 had taken at least one herbal remedy and six of these developed an ADR. Five ADR-drug associations (hypokalaemia with methylprednisolone, increased transaminase levels with standard antituberculosis drugs, upper gastrointestinal bleeding with nonsteroidal anti-inflammatory drugs, constipation with tramadol, and increased transaminase levels with herbal remedies) represented 18 (27. 7%) of the 65 ADRs in this study. According to the Schumock and Thornton preventability scale, more than half of these ADRs (35 [53. 9%]) were preventable. The present study highlights the existence of ADRs among patients attending these hospitals. The implementation of active pharmacovigilance in hospitals could be a helpful first step to improving the awareness of unwanted effects of medicines and patient safety, as well as a way to strengthen the national pharmacovigilance system in countries such as Myanmar. The online version of this article (10. 1007/s40801-020-00180-0) contains supplementary material, which is available to authorized users.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Published in: Drugs - Real World Outcomes, Vol. 7 (february 2020) , p. 109-117, ISSN 2198-9788

DOI: 10.1007/s40801-020-00180-0
PMID: 32040848


9 p, 792.8 KB

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 Record created 2020-07-06, last modified 2023-10-01



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