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Página principal > Artículos > Artículos publicados > Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma |
Fecha: | 2019 |
Resumen: | The online version of this article (10. 1007/s00018-019-03041-4) contains supplementary material, which is available to authorized users. |
Resumen: | Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the genome, remains largely unexplored. RNA therapeutics is an emerging field that widens the range of druggable targets and includes elements such as microRNA. Here, we sought to screen for microRNA with tumor-suppressive functions in neuro-blastoma, an aggressive pediatric tumor of the sympathetic nervous system that requires the development of new therapies. We found miR-323a-5p and miR-342-5p to be capable of reducing cell proliferation in multiple neuroblastoma cell lines in vitro and in vivo, thereby providing a proof of concept for miRNA-based therapies for neuroblastoma. Furthermore, the combined inhibition of the direct identified targets such as CCND1, CHAF1A, INCENP and BCL-XL could reveal new vulnerabilities of high-risk neuroblastoma. |
Ayudas: | Ministerio de Educación, Cultura y Deporte FPU16-01099 Instituto de Salud Carlos III CP11-00052 Instituto de Salud Carlos III CP16-00006 Instituto de Salud Carlos III PI14-00561 Instituto de Salud Carlos III PI14-00647 Instituto de Salud Carlos III PI17-00564 Instituto de Salud Carlos III RD12-0036-0016 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-660 |
Nota: | Altres ajuts: Fundación Científica Asociación Española Contra el Cáncer (Grant no. AECC-JB-2012-01). |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Pediatric cancer ; Non-coding RNA ; High-throughput screening ; 14q32 ; Epigenetics ; Cancer therapy |
Publicado en: | Cellular and Molecular Life Sciences, Vol. 76 (february 2019) , p. 2231-2243, ISSN 1420-9071 |
13 p, 6.2 MB |