Tumour characteristics and survivorship in a cohort of breast cancer : the MCC-Spain study
Gomez-Acebo, Ines (Universidad de Cantabria)
Dierssen-Sotos, Trinidad (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria))
Palazuelos-Calderón, Camilo (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria))
Pérez-Gómez, Beatriz (Instituto de Salud Carlos III)
Amiano, Pilar (Biodonostia Osasun Ikerketako Institutura (País Basc))
Guevara, Marcela (Instituto de Investigación Sanitaria de Navarra)
Molina, Antonio J. (Instituto de Biomedicina, León)
Domingo, Laia (Institut Hospital del Mar d'Investigacions Mèdiques)
Fernández-Ortiz, María (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria))
Moreno Aguado, Víctor (Institut d'Investigació Biomèdica de Bellvitge)
Alguacil, Juan (Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente, Huelva)
Fernández-Tardon, Guillermo (Instituto de Investigación Sanitaria del Principado de Asturias)
Ibáñez, Josefa (Fundació FISABIO, València)
Marcos-Gragera, Rafael (Institut Català d'Oncologia)
Diaz-Santos, Marian (Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente, Huelva)
Alonso, M. Henar (Institut d'Investigació Biomèdica de Bellvitge)
Alonso-Molero, Jessica (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria))
Castaño-Vinyals, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques)
García Palomo, Andrés (Complejo Asistencial Universitario de León)
Ardanaz, Eva (Instituto de Investigación Sanitaria de Navarra)
Molinuevo, Amaia (Biodonostia Osasun Ikerketako Institutura (País Basc))
Aragonés, Nuria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Kogevinas, M.. (Institut Hospital del Mar d'Investigacions Mèdiques)
Pollán, Marina (Instituto de Salud Carlos III)
Llorca, Javier (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria))
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Among components of TNM staging system, tumour size greater than 50 mm (i. e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2. 31, 4. 00, 4. 94, 7. 92, 2. 26, 14. 9 and 58. 9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased The online version of this article (10. 1007/s10549-020-05600-x) contains supplementary material, which is available to authorised users.
Grants:	Instituto de Salud Carlos III PI08/1770 Instituto de Salud Carlos III PI08/0533 Instituto de Salud Carlos III PI08/1359 Instituto de Salud Carlos III PI09/00773 Instituto de Salud Carlos III PI09/01286 Instituto de Salud Carlos III PI09/01903 Instituto de Salud Carlos III PI09/02078 Instituto de Salud Carlos III PI09/01662 Instituto de Salud Carlos III PI11/01403 Instituto de Salud Carlos III PI11/01889 Instituto de Salud Carlos III PI11/00226 Instituto de Salud Carlos III PI11/01810 Instituto de Salud Carlos III PI11/02213 Instituto de Salud Carlos III PI12/00488 Instituto de Salud Carlos III PI12/00265 Instituto de Salud Carlos III PI12/01270 Instituto de Salud Carlos III PI12/00715 Instituto de Salud Carlos III PI12/00150 Instituto de Salud Carlos III PI14/01219 Instituto de Salud Carlos III PI14/00613 Instituto de Salud Carlos III PI15/00069 European Commission 036224 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-647
Note:	Altres ajuts: Fundación Marqués de Valdecilla (grant API 10/09); Recercaixa (grant 2010ACUP 00310).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cohort ; Epidemiology ; Breast cancer ; Relative survival ; MCC-spain
Published in:	Breast Cancer Research and Treatment, Vol. 181 (april 2020) , p. 667-678, ISSN 1573-7217

DOI: 10.1007/s10549-020-05600-x
PMID: 32356254

12 p, 932.4 KB

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