Histopathological characterisation of retinal lesions associated to Diplostomum species (Platyhelminthes : Trematoda) infection in polymorphic Arctic charr Salvelinus alpinus
Padrós, Francesc, 1965-, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Knudsen, R. (UiT The Arctic University of Norway. Department of Arctic and Marine Biology)
Blasco-Costa, I. (Natural History Museum of Geneva)

Fecha:	2018
Resumen:	The eye represents an immune privileged organ where parasites can escape host reactions. This study provides the first systematic evidence of the pathology associated with Diplostomum sp. infection in the eye retina of fish (i. e. Arctic charr). Histological sections showed that the trematodes caused mechanical disengagement between the retinal pigmentary epithelium and the neurosensory retina, with damaged cones and rods in the outer segment and epithelium reduced to a single layer of pigmentary cells. The metacercariae were "floating" in possibly fluid-filled vesicles together with several round cells, mostly located in the anterio-dorsal and anterio-ventral areas of the eye near the iris. The round cells may indicate internal retinal damage repair mechanisms, without connections to the general immune system. Metacercariae intestines contained pigmented cellular debris indicating that they feed on retinal epithelium. These retinal lesions may have similar vision effects as focal retinal detachment in vertebrates. Diplostomum metacercaria alters fish visual acuity but may in a lesser degree lead to a severe or total visual impairment because of repairing mechanisms. The pathology in the retina seems thereby to be dependent on fish size, age and dose.
Nota:	Altres ajuts: SNSF/31003A_169211/1
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Helminths ; Eyeflukes ; Retina ; Pathology ; Salmonidae ; Freshwater
Publicado en:	International Journal for Parasitology: Parasites and Wildlife, Vol. 7 (january 2018) , p. 68-74, ISSN 2213-2244

DOI: 10.1016/j.ijppaw.2018.01.007
PMID: 29988817

7 p, 1.3 MB

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