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| Página principal > Artículos > Artículos publicados > Effect of mistimed eating patterns on breast and prostate cancer risk (MCC-Spain Study) |
(Institut Hospital del Mar d'Investigacions Mèdiques) (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) (Universidad de Alcalá) (Instituto de Investigación Marqués de Valdecilla) (Instituto de Investigación Sanitaria de Navarra) (Centro de Investigación en Recursos Naturales, Salud, y Medio Ambiente (RENSMA), Universidad de Huelva) (Universitat de Barcelona) (Instituto Universitario de Oncología, Universidad de Oviedo) (Institut d'Investigació Biomèdica de Girona) (National Centre for Epidemiology, Carlos III Institute of Health) (Instituto de Investigación Marqués de Valdecilla) (Instituto de Investigación Sanitaria de Navarra) (Universidad de León. Instituto de Biomedicina) (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) (CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))| Fecha: | 2018 |
| Resumen: | Modern life involves mistimed sleeping and eating patterns that in experimental studies are associated with adverse health effects. We assessed whether timing of meals is associated with breast and prostate cancer risk taking into account lifestyle and chronotype, a characteristic correlating with preference for morning or evening activity. We conducted a population-based case-control study in Spain, 2008-2013. In this analysis we included 621 cases of prostate and 1,205 of breast cancer and 872 male and 1,321 female population controls who had never worked night shift. Subjects were interviewed on timing of meals, sleep and chronotype and completed a Food Frequency Questionaire. Adherence to the World Cancer Research Fund/American Institute of Cancer Research recommendations for cancer prevention was examined. Compared with subjects sleeping immediately after supper, those sleeping two or more hours after supper had a 20% reduction in cancer risk for breast and prostate cancer combined (adjusted Odds Ratio [OR] = 0. 80, 95%CI 0. 67-0. 96) and in each cancer individually (prostate cancer OR = 0. 74, 0. 55-0. 99; breast cancer OR = 0. 84, 0. 67-1. 06). A similar protection was observed in subjects having supper before 9 pm compared with supper after 10 pm. The effect of longer supper-sleep interval was more pronounced among subjects adhering to cancer prevention recommendations (OR both cancers= 0. 65, 0. 44-0. 97) and in morning types (OR both cancers = 0. 66, 0. 49-0. 90). Adherence to diurnal eating patterns and specifically a long interval between last meal and sleep are associated with a lower cancer risk, stressing the importance of evaluating timing in studies on diet and cancer. What's new? Evidence shows that long-term disruption of endogenous circadian rhythms may be associated with cancer. The effects of mistimed sleeping and eating patterns that come with modern life are however less clear. This large Spanish population-based study examined whether meal timing and sleep patterns are associated with the two most common nightshift-related cancers. Adherence to a more diurnal eating pattern, and specifically an early supper and a long interval between last meal and sleep were associated with a lower breast and prostate cancer risk, stressing the importance of evaluating circadian rhythms in diet and cancer studies and revisiting recommendations for prevention. |
| Ayudas: | Instituto de Salud Carlos III FEDER/PI11-01889 Instituto de Salud Carlos III PI08-1770 Instituto de Salud Carlos III FEDER/PI08-0533 Instituto de Salud Carlos III FEDER/PI08-1359 Instituto de Salud Carlos III FEDER/PI09-00773-Cantabria Instituto de Salud Carlos III FEDER/PI09-01286-Leon Instituto de Salud Carlos III FEDER/PI09-01903-Valencia Instituto de Salud Carlos III FEDER/PI09-02078-Huelva Instituto de Salud Carlos III FEDER/PI09-01662-Granada Instituto de Salud Carlos III FEDER/PI11-01889-FEDER Instituto de Salud Carlos III FEDER/PI11-02213 Instituto de Salud Carlos III FEDER/PI12-00488 Instituto de Salud Carlos III FEDER/PI12-00265 Instituto de Salud Carlos III FEDER/PI12-01270 Instituto de Salud Carlos III FEDER/PI12-00715 Instituto de Salud Carlos III FEDER/PI14-0613 Instituto de Salud Carlos III FEDER/PI15-00069 Instituto de Salud Carlos III FEDER/PI15-00914 Instituto de Salud Carlos III FEDER/PI15-01032 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014SGR647 |
| Nota: | Altres ajuts: Grant sponsor: Regional Government of the Basque Country; Grant sponsor: Consejerıa de Sanidad de la Region de Murcia; Grant sponsor: European Commission grants FOOD-CT-2006-036224-HIWATE; Grant sponsor: Spanish Association Against Cancer (AECC) Scientific Foundation; Grant sponsor: Fundacion Caja de Ahorros de Asturias and by the University of Oviedo |
| Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Lengua: | Anglès |
| Documento: | Article ; recerca ; Versió publicada |
| Materia: | Breast cancer ; Prostate cancer ; Diet ; Circadian disruption |
| Publicado en: | International Journal of Cancer, Vol. 143 (july 2018) , p. 2380-2389, ISSN 1097-0215 |
