Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
Berasategui, Barbara (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Fonollosa, Alex (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Artaraz, Joseba (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Ruiz Arruza, Ioana (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Ríos, Jose (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Matas, Jessica (Hospital Clínic i Provincial de Barcelona)
Llorenç, Victor (Hospital Clínic i Provincial de Barcelona)
Diaz Valle, David (Hospital Clínico San Carlos (Madrid))
Sastre Ibañez, Marina (Hospital Clínico San Carlos (Madrid))
Arriola Villalobos, Pedro (Hospital Clínico San Carlos (Madrid))
Adan Civera, Alfredo (Hospital Clínic i Provincial de Barcelona)

Date:	2018
Abstract:	Hyperreflective foci have been described in OCT imaging of patients with retinal vascular diseases. It has been suggested that they may play a role as a prognostic factor of visual outcomes in these diseases. The purpose of this study is to describe the presence of hyperreflective foci in patients with non-infectious uveitic macular edema and evaluate their behavior after treatment. We conducted a multicenter, prospective, observational, 12-month follow-up study. Inclusion criteria were age > 18 years and a diagnosis of non-infectious uveitic macular edema, defined as central macular thickness of > 300 μm as measured by OCT and fluid in the macula. Collected data included best corrected visual acuity, central macular thickness and the presence, number and distribution (inner or outer retinal layers) of hyperreflective foci. Evaluations were performed at baseline, and at 1, 3, 6, and 12 months after starting treatment. We included 24 eyes of 24 patients. The frequency of patients with ≥11 hyperreflective foci was 58. 4% at baseline, falling to 20. 8% at 12 months. Further, hyperreflective foci were observed in the outer retinal layers in 50% of patients at baseline and just 28. 6% at 12 months. Mean LogMAR visual acuity improved from 0. 55 (95% CI 0. 4–0. 71) at baseline to 0. 22 (95% CI 0. 08–0. 35) at 12 months (p < 0. 001). Mean central macular thickness decreased from 453. 83 μm (95% CI 396. 6–511) at baseline to 269. 32 μm (95% CI 227. 7–310. 9) at 12 months (P < 0. 001). Central macular thickness was associated with number (p = 0. 017) and distribution (p = 0. 004) of hyperreflective foci. We have observed hyperreflective foci in most of our patients with non-infectious uveitic macular edema. During follow-up and after treatment, the number of foci diminished and they tended to be located in the inner layers of the retina.
Grants:	Instituto de Salud Carlos III PI-13-02148
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Hyperreflective foci ; Intraocular inflammation ; Microglia ; Optical coherence tomography ; Uveitic macular edema ; Uveitis
Published in:	BMC ophthalmology, Vol. 18 (july 2018) , ISSN 1471-2415

DOI: 10.1186/s12886-018-0848-5
PMID: 30029623

9 p, 1.0 MB

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