Web of Science: 11 citas, Scopus: 11 citas, Google Scholar: citas,
Changes in salivary analytes in canine parvovirus : A high-resolution quantitative proteomic study
Franco-Martínez, Lorena (Universidad de Murcia. Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU. Regional Campus of International Excellence Mare Nostrum.)
Tvarijonaviciute, Asta (Universidad de Murcia. Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU. Regional Campus of International Excellence Mare Nostrum.)
Horvatić, Anita (University of Zagreb. Internal Diseases Clinic, Faculty of Veterinary Medicine)
Guillemin, Nicolas (University of Zagreb. Internal Diseases Clinic, Faculty of Veterinary Medicine)
Cerón, José Joaquín (Universidad de Murcia. Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU. Regional Campus of International Excellence Mare Nostrum.)
Escribano, Damián (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Eckersall, David (University of Glasgow. Institute of Biodiversity, Animal Health and Comparative Medicine)
Kocatürk, Meriç (Uludag University. Department of Internal Medicine. Faculty of Veterinary Medicine)
Yilmaz, Zeki (Uludag University. Department of Internal Medicine. Faculty of Veterinary Medicine)
Lamy, Elsa (Universidad de Evora. ICAAM - Institute of Mediterranean Agricultural and Environmental Sciences)
Martínez-Subiela, Silvia (Universidad de Murcia. Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU. Regional Campus of International Excellence Mare Nostrum.)
Mrljak, Vladimir (University of Zagreb. Internal Diseases Clinic, Faculty of Veterinary Medicine)

Fecha: 2018
Resumen: The present study evaluated the changes in salivary proteome in parvoviral enteritis (PVE) in dogs through a high-throughput quantitative proteomic analysis. Saliva samples from healthy dogs and dogs with severe parvovirosis that survived or perished due to the disease were analysed and compared by Tandem Mass Tags (TMT) analysis. Proteomic analysis quantified 1516 peptides, and 287 (corresponding to 190 proteins) showed significantly different abundances between studied groups. Ten proteins were observed to change significantly between dogs that survived or perished due to PVE. Bioinformatics' analysis revealed that saliva reflects the involvement of different pathways in PVE such as catalytic activity and binding, and indicates antimicrobial humoral response as a pathway with a major role in the development of the disease. These results indicate that saliva proteins reflect physiopathological changes that occur in PVE and could be a potential source of biomarkers for this disease.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès
Documento: article ; recerca ; publishedVersion
Materia: Bioinformatics ; Biomarker ; Canine parvovirosis ; Dog ; Label-based proteomics ; Saliva
Publicado en: Comparative Immunology, Microbiology and Infectious Diseases, Vol. 60 October (2018) , p. 1-10

DOI: 10.1016/j.cimid.2018.09.011
PMID: 30396423


11 p, 3.6 MB

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